PURPOSE: The purpose of this work was to determine the precision and diagnostic efficacy of bone mineral density (BMD) measures based on volumetric quantitative CT (QCT) of the spine. METHOD: Volumetric CT scans of L1 and L2 (GE-9800Q; 80 kVp, 140 mAs, 3 mm slices) were acquired in a cohort of 62 osteoporotic women (mean age 70.4 years, T(DXA hip or spine) < -2.5), of whom 20 had vertebral fractures and 42 were nonfractured control subjects. An image analysis technique delineated trabecular, cortical, and integral regions in reference to a vertebra-fixed coordinate system. We computed precision values and fracture control differences for these new regions and for single-slice QCT and dual X-ray absorptiometry (DXA) measures synthesized from the volumetric data. RESULTS: Volumetric trabecular BMD showed higher precision (1.3%) than the synthesized single-slice measures (2.1-2.8%). Volumetric and single-slice trabecular BMD showed equivalent decrements between fractured and nonfractured subjects (17-19%), with integral BMD showing smaller and less significant differences (7-8%). CONCLUSION: Volumetric and single-slice QCT techniques are equivalent for vertebral fracture risk estimation, but volumetric techniques should be superior for monitoring therapy efficacy.
PURPOSE: The purpose of this work was to determine the precision and diagnostic efficacy of bone mineral density (BMD) measures based on volumetric quantitative CT (QCT) of the spine. METHOD: Volumetric CT scans of L1 and L2 (GE-9800Q; 80 kVp, 140 mAs, 3 mm slices) were acquired in a cohort of 62 osteoporoticwomen (mean age 70.4 years, T(DXA hip or spine) < -2.5), of whom 20 had vertebral fractures and 42 were nonfractured control subjects. An image analysis technique delineated trabecular, cortical, and integral regions in reference to a vertebra-fixed coordinate system. We computed precision values and fracture control differences for these new regions and for single-slice QCT and dual X-ray absorptiometry (DXA) measures synthesized from the volumetric data. RESULTS: Volumetric trabecular BMD showed higher precision (1.3%) than the synthesized single-slice measures (2.1-2.8%). Volumetric and single-slice trabecular BMD showed equivalent decrements between fractured and nonfractured subjects (17-19%), with integral BMD showing smaller and less significant differences (7-8%). CONCLUSION: Volumetric and single-slice QCT techniques are equivalent for vertebral fracture risk estimation, but volumetric techniques should be superior for monitoring therapy efficacy.
Authors: Hugo Giambini; Dan Dragomir-Daescu; Paul M Huddleston; Jon J Camp; Kai-Nan An; Ahmad Nassr Journal: J Biomech Eng Date: 2015-11 Impact factor: 2.097
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Authors: Anne L Schafer; Connie M Weaver; Dennis M Black; Amber L Wheeler; Hanling Chang; Gina V Szefc; Lygia Stewart; Stanley J Rogers; Jonathan T Carter; Andrew M Posselt; Dolores M Shoback; Deborah E Sellmeyer Journal: J Bone Miner Res Date: 2015-05-21 Impact factor: 6.741
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