Literature DB >> 1002148

Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.

J Herha, G Obe.   

Abstract

We analyzed the leukocyte chromosomes of 10 epileptic probands on monotherapy with carbamazepine (CP), of 14 epileptic probands on monotherapy with diphenylhydantoin (DPH) and of 20 clinically normal probands (controls, CO). In the CP and in the DPH group we found a significant elevation of exchange-type aberrations as compared to the CO group. In the CP group we found predominantly chromatid translocations, in the DPH group exclusively dicentric chromosomes.

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Year:  1976        PMID： 1002148     DOI： 10.1007/BF00295288

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  [Effects of anticonvulsive treatment on drug elimination in man. Induction of liver hydroxylating enzyme system by diphenylhydantoin and carbamazepine].

Authors:  F Petruch; R V Schüppel
Journal:  Bibl Psychiatr       Date:  1975

2.  The human leukocyte test system. V. DNA synthesis and mitoses in PHA-stimulated 3-day cultures.

Authors:  G Obe; B Beek; G Dudin
Journal:  Humangenetik       Date:  1975-08-25

3.  Chromosomal damage in chronic alcohol users.

Authors:  G Obe; J Herha
Journal:  Humangenetik       Date:  1975-09-23

4.  Determination of diphenylhydantoin and phenobarbital in small amounts of serum.

Authors:  O SVENSMARK; P KRISTENSEN
Journal:  J Lab Clin Med       Date:  1963-03

5.  The importance of individual pharmacokinetic data for treatment of epilepsy with carbamazepine.

Authors:  L W Diehl; B Müller-Oerlinghausen; E Riedel
Journal:  Int J Clin Pharmacol Biopharm       Date:  1976-09

6.  Chronic antiepileptic toxicity: a review.

Authors:  E H Reynolds
Journal:  Epilepsia       Date:  1975-06       Impact factor: 5.864

7.  The human leukocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures.

Authors:  G Dudin; B Beek; G Obe
Journal:  Mutat Res       Date:  1974-05       Impact factor: 2.433

8.  Do anticonvulsants have a teratogenic effect?

Authors:  J F Annegers; L R Elveback; W A Hauser; L T Kurland
Journal:  Arch Neurol       Date:  1974-12

9.  The human leukocyte test system. III. Premature chromosome condensation from chemically and x-ray induced micronuclei.

Authors:  G Obe; B Beek; V G Vaidya
Journal:  Mutat Res       Date:  1975-01       Impact factor: 2.433

10.  The human leulocyte test system. VII. Further investigations concerning micronucleus-derived premature chromosome condensation.

Authors:  G Obe; B Beek
Journal:  Humangenetik       Date:  1975-11-06
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  5 in total

1.  Increased chromosomal breakage in epileptic children after long-term treatment.

Authors:  P Curatolo; V Brinchi; R Cusmai; P Vignetti; P Benedetti
Journal:  Eur J Pediatr       Date:  1986-10       Impact factor: 3.183

2.  Beta-thalassaemia: increased chromosomal anomalies in lymphocyte cultures.

Authors:  G B Côté; S Papadakou-Lagoyanni
Journal:  J Med Genet       Date:  1979-02       Impact factor: 6.318

3.  Chromosomal aberrations in heavy smokers.

Authors:  G Obe; J Herha
Journal:  Hum Genet       Date:  1978-04-24       Impact factor: 4.132

4.  Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy.

Authors:  F Kotlarek; J Faust
Journal:  Hum Genet       Date:  1978-09-19       Impact factor: 4.132

5.  Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone.

Authors:  K J Esser; F Kotlarek; M Habedank; U Mühler; E Mühler
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132
  5 in total

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