Literature DB >> 1165099

Chromosomal damage in chronic alcohol users.

G Obe, J Herha.   

Abstract

First in vitro mitoses were analysed from the peripheral leukocytes of 22 chronic alcohol users and of 18 controls. The frequency of exchange aberrations of the chromatid and chromosome type were significantly higher in the alcohol as compared with the control group. The results indicate an indirect or direct mutagenic activity of alcohol in vivo.

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Year:  1975        PMID： 1165099     DOI： 10.1007/bf00297623

Source DB:  PubMed          Journal:  Humangenetik        ISSN： 0018-7348


  7 in total

1.  Premature chromosome condensation in a case of Fanconi's anemia.

Authors:  G Obe; J B Lüdcke; K Waldenmaier; K Sperling
Journal:  Humangenetik       Date:  1975-06-19

2.  Induction of dominant lethal mutation in male mice by ethyl alcohol.

Authors:  F M Badr; R S Badr
Journal:  Nature       Date:  1975-01-10       Impact factor: 49.962

3.  The human leukocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures.

Authors:  G Dudin; B Beek; G Obe
Journal:  Mutat Res       Date:  1974-05       Impact factor: 2.433

4.  [Types and expansion of alcoholism].

Authors:  P Kielholz
Journal:  Dtsch Med J       Date:  1972-08

Review 5.  Toxicological and pharmacological properties of clomethiazole.

Authors:  P Lechat
Journal:  Acta Psychiatr Scand Suppl       Date:  1966

6.  The human leukocyte test system. III. Premature chromosome condensation from chemically and x-ray induced micronuclei.

Authors:  G Obe; B Beek; V G Vaidya
Journal:  Mutat Res       Date:  1975-01       Impact factor: 2.433

7.  Premature chromosme condensation in the bone marrow of Chinese hamster after application of bleomycin in vivo.

Authors:  S Kürten; G Obe
Journal:  Mutat Res       Date:  1975-02       Impact factor: 2.433
  7 in total
  8 in total

1.  No elevation of exchange type aberrations in lymphocytes of children with alcohol embryopathy.

Authors:  G Obe; F Majewski
Journal:  Hum Genet       Date:  1978-07-12       Impact factor: 4.132

2.  Chromosomal abnormalities in ascitic fluid from patients with alcoholic cirrhosis.

Authors:  A To; H T Boyo-Ekwueme; M C Posnansky; D V Coleman
Journal:  Br Med J (Clin Res Ed)       Date:  1981-05-23

3.  Increased frequency of sister-chromatid exchanges in alcoholics.

Authors:  M G Butler; W G Sanger; G E Veonett
Journal:  Mutat Res       Date:  1981-04       Impact factor: 2.433

4.  Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy.

Authors:  F Kotlarek; J Faust
Journal:  Hum Genet       Date:  1978-09-19       Impact factor: 4.132

5.  Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay.

Authors:  J U Böhlke; S Singh; H W Goedde
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

Review 6.  Methods for analysis of the mutagenicity of indirect mutagens/carcinogens in eukaryotic cells.

Authors:  S Madle; G Obe
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

7.  Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro.

Authors:  S Madle; G Obe; H Schroeter; J Herha; A Pietzcker
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

8.  Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.

Authors:  J Herha; G Obe
Journal:  Hum Genet       Date:  1976-12-15       Impact factor: 4.132
  8 in total

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