Literature DB >> 9973366

The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.

Y Ohashi1, Y Chijiiwa, K Suzuki, K Takahashi, H Nanamiya, T Sato, Y Hosoya, K Ochi, F Kawamura.   

Abstract

3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 9973366      PMCID： PMC93517     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  24 in total

1.  The essential bacterial cell-division protein FtsZ is a GTPase.

Authors:  P de Boer; R Crossley; L Rothfield
Journal:  Nature       Date:  1992-09-17       Impact factor: 49.962

2.  The possible role of ADP-ribosylation in sporulation and streptomycin production by Streptomyces griseus.

Authors:  K Ochi; A Penyige; G Barabas
Journal:  J Gen Microbiol       Date:  1992-08

3.  FtsZ, a tubulin homologue in prokaryote cell division.

Authors:  H P Erickson
Journal:  Trends Cell Biol       Date:  1997-09       Impact factor: 20.808

4.  FtsZ ring structure associated with division in Escherichia coli.

Authors:  E F Bi; J Lutkenhaus
Journal:  Nature       Date:  1991-11-14       Impact factor: 49.962

5.  The Bacillus subtilis spoIIG operon encodes both sigma E and a gene necessary for sigma E activation.

Authors:  R M Jonas; E A Weaver; T J Kenney; C P Moran; W G Haldenwang
Journal:  J Bacteriol       Date:  1988-02       Impact factor: 3.490

6.  Processing of a sporulation sigma factor in Bacillus subtilis: how morphological structure could control gene expression.

Authors:  P Stragier; C Bonamy; C Karmazyn-Campelli
Journal:  Cell       Date:  1988-03-11       Impact factor: 41.582

7.  FtsZ in Bacillus subtilis is required for vegetative septation and for asymmetric septation during sporulation.

Authors:  B Beall; J Lutkenhaus
Journal:  Genes Dev       Date:  1991-03       Impact factor: 11.361

8.  Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein.

Authors:  D RayChaudhuri; J T Park
Journal:  Nature       Date:  1992-09-17       Impact factor: 49.962

9.  Cloning and characterization of Bacillus subtilis homologs of Escherichia coli cell division genes ftsZ and ftsA.

Authors:  B Beall; M Lowe; J Lutkenhaus
Journal:  J Bacteriol       Date:  1988-10       Impact factor: 3.490

Review 10.  Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin.

Authors:  B D Spangler
Journal:  Microbiol Rev       Date:  1992-12
View more
  21 in total

1.  Developmental regulation of the cell division protein FtsZ in Anabaena sp. strain PCC 7120, a cyanobacterium capable of terminal differentiation.

Authors:  I Kuhn; L Peng; S Bedu; C C Zhang
Journal:  J Bacteriol       Date:  2000-08       Impact factor: 3.490

Review 2.  FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.

Authors:  Harold P Erickson; David E Anderson; Masaki Osawa
Journal:  Microbiol Mol Biol Rev       Date:  2010-12       Impact factor: 11.056

3.  Practical synthesis of PC190723, an inhibitor of the bacterial cell division protein FtsZ.

Authors:  Nohemy A Sorto; Marilyn M Olmstead; Jared T Shaw
Journal:  J Org Chem       Date:  2010-10-29       Impact factor: 4.354

Review 4.  Challenges of antibacterial discovery.

Authors:  Lynn L Silver
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

Review 5.  Discovery of anti-TB agents that target the cell-division protein FtsZ.

Authors:  Kunal Kumar; Divya Awasthi; William T Berger; Peter J Tonge; Richard A Slayden; Iwao Ojima
Journal:  Future Med Chem       Date:  2010-08       Impact factor: 3.808

6.  A Bacterial Cell Shape-Determining Inhibitor.

Authors:  Yanjie Liu; Emilisa Frirdich; Jennifer A Taylor; Anson C K Chan; Kris M Blair; Jenny Vermeulen; Reuben Ha; Michael E P Murphy; Nina R Salama; Erin C Gaynor; Martin E Tanner
Journal:  ACS Chem Biol       Date:  2016-01-15       Impact factor: 5.100

Review 7.  Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.

Authors:  Krupanandan Haranahalli; Simon Tong; Iwao Ojima
Journal:  Bioorg Med Chem       Date:  2016-05-05       Impact factor: 3.641

8.  Borrelia burgdorferi ftsZ plays a role in cell division.

Authors:  Lydia Dubytska; Henry P Godfrey; Felipe C Cabello
Journal:  J Bacteriol       Date:  2006-03       Impact factor: 3.490

9.  An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.

Authors:  Neil R Stokes; Nicola Baker; James M Bennett; Joanne Berry; Ian Collins; Lloyd G Czaplewski; Alastair Logan; Rebecca Macdonald; Leanne Macleod; Hilary Peasley; Jeffrey P Mitchell; Narendra Nayal; Anju Yadav; Anil Srivastava; David J Haydon
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

10.  Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor.

Authors:  David E Anderson; Michelle B Kim; Jared T Moore; Terrence E O'Brien; Nohemy A Sorto; Charles I Grove; Laura L Lackner; James B Ames; Jared T Shaw
Journal:  ACS Chem Biol       Date:  2012-10-05       Impact factor: 5.100
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.