Literature DB >> 99668

Evidence for splicing of interrupted immunoglobulin variable and constant region sequences in nuclear RNA.

T H Rabbitts.   

Abstract

Evidence is presented that the mouse light-chain coding sequence is interrupted in a 27S nuclear RNA species, whereas the sequence is continuous in both a 13S nuclear RNA and in cytoplasmic mRNA. The discontinuity of coding regions in the 27S nuclear RNA parallels the situation found in myeloma DNA and indicates, therefore, that the removal of interruptions in the V and C regions occurs at the level of nuclear RNA.

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Year:  1978        PMID： 99668     DOI： 10.1038/275291a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  14 in total

1.  Comparison of mRNA precursors in plasmacytomas producing closely related kappa chains.

Authors:  R P Perry; D E Kelley; U Schibler
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

2.  Coexpression of mu and gamma 1 heavy chains can occur by a discontinuous transcription mechanism from the same unrearranged chromosome.

Authors:  M Nolan-Willard; M T Berton; P Tucker
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

3.  Molecular analysis of neonatal IgA expression: implications for class switching, allelic polymorphism and somatic mutation.

Authors:  S L Jones; J M Teale; S C Riley; N R Klinman; P W Tucker
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

4.  General occurrence and transcription of intervening sequences in mouse genes expressed via polyadenylated mRNA.

Authors:  I H Maxwell; F Maxwell; W E Hahn
Journal:  Nucleic Acids Res       Date:  1980-12-11       Impact factor: 16.971

5.  Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors.

Authors:  B C Trapnell; P Tolstoshev; R G Crystal
Journal:  Nucleic Acids Res       Date:  1980-08-25       Impact factor: 16.971

6.  The sequence at the 3' terminus of mouse immunoglobulin secreted mu chain messenger RNA determined from cloned cDNA.

Authors:  G Matthyssens; T H Rabbitts
Journal:  Nucleic Acids Res       Date:  1980-02-25       Impact factor: 16.971

7.  Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

Authors:  G Matthyssens; T H Rabbitts
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

8.  Species nonspecific fraction of non-histone chromatin proteins in mice and rats immunized with bacterial lipopolysaccharides.

Authors:  A Horst; E M Rakowicz-Szulczyńska
Journal:  Mol Cell Biochem       Date:  1981-06-09       Impact factor: 3.396

9.  High-molecular-weight nuclear polyadenylate-containing ribonucleic acid isolated from the lactating guniea-pig mammary gland contains milk-protein messenger ribonucleic acid sequences.

Authors:  I C Bathurst; R K Craig; P N Campbell
Journal:  Biochem J       Date:  1979-08-01       Impact factor: 3.857

10.  In vitro splicing of SV40 late mRNA in isolated nuclei from CV-1 cells.

Authors:  H Hamada; T Igarashi; M Muramatsu
Journal:  Nucleic Acids Res       Date:  1980-02-11       Impact factor: 16.971
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