Literature DB >> 9933168

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.

A Peled1, I Petit, O Kollet, M Magid, T Ponomaryov, T Byk, A Nagler, H Ben-Hur, A Many, L Shultz, O Lider, R Alon, D Zipori, T Lapidot.   

Abstract

Stem cell homing and repopulation are not well understood. The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 were found to be critical for murine bone marrow engraftment by human severe combined immunodeficient (SCID) repopulating stem cells. Treatment of human cells with antibodies to CXCR4 prevented engraftment. In vitro CXCR4-dependent migration to SDF-1 of CD34+CD38-/low cells correlated with in vivo engraftment and stem cell function. Stem cell factor and interleukin-6 induced CXCR4 expression on CD34+ cells, which potentiated migration to SDF-1 and engraftment in primary and secondary transplanted mice. Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation.

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Year:  1999        PMID： 9933168     DOI： 10.1126/science.283.5403.845

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  488 in total

1.  Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.

Authors:  F C Yang; S J Atkinson; Y Gu; J B Borneo; A W Roberts; Y Zheng; J Pennington; D A Williams
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

2.  Umbilical cord blood: an expandable resource.

Authors:  M A Moore
Journal:  J Clin Invest       Date:  2000-04       Impact factor: 14.808

3.  Cell contact regulates fate choice by cortical stem cells.

Authors:  R Y Tsai; R D McKay
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

4.  Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function.

Authors:  T Ponomaryov; A Peled; I Petit; R S Taichman; L Habler; J Sandbank; F Arenzana-Seisdedos; A Magerus; A Caruz; N Fujii; A Nagler; M Lahav; M Szyper-Kravitz; D Zipori; T Lapidot
Journal:  J Clin Invest       Date:  2000-12       Impact factor: 14.808

Review 5.  Regulation of hematopoiesis by chemokine family members.

Authors:  H E Broxmeyer
Journal:  Int J Hematol       Date:  2001-07       Impact factor: 2.490

6.  Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin.

Authors:  J L Pablos; A Amara; A Bouloc; B Santiago; A Caruz; M Galindo; T Delaunay; J L Virelizier; F Arenzana-Seisdedos
Journal:  Am J Pathol       Date:  1999-11       Impact factor: 4.307

Review 7.  The new stem cell biology: something for everyone.

Authors:  S L Preston; M R Alison; S J Forbes; N C Direkze; R Poulsom; N A Wright
Journal:  Mol Pathol       Date:  2003-04

8.  Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells.

Authors:  Chad M Novince; Amy J Koh; Megan N Michalski; Julie T Marchesan; Jason Wang; Younghun Jung; Janice E Berry; Matthew R Eber; Thomas J Rosol; Russell S Taichman; Laurie K McCauley
Journal:  Am J Pathol       Date:  2011-09-21       Impact factor: 4.307

Review 9.  Inflammation and cerebral aneurysms.

Authors:  Koji Hosaka; Brian L Hoh
Journal:  Transl Stroke Res       Date:  2013-12-11       Impact factor: 6.829

10.  Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance.

Authors:  Satish Khurana; Lia Margamuljana; Chacko Joseph; Sarah Schouteden; Shannon M Buckley; Catherine M Verfaillie
Journal:  Blood       Date:  2013-01-17       Impact factor: 22.113
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