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Literature DB >> 11104786

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function.

T Ponomaryov¹, A Peled, I Petit, R S Taichman, L Habler, J Sandbank, F Arenzana-Seisdedos, A Magerus, A Caruz, N Fujii, A Nagler, M Lahav, M Szyper-Kravitz, D Zipori, T Lapidot.

Abstract

The chemokine stromal-derived factor-1 (SDF-1) controls many aspects of stem cell function. Details of its regulation and sites of production are currently unknown. We report that in the bone marrow, SDF-1 is produced mainly by immature osteoblasts and endothelial cells. Conditioning with DNA-damaging agents (ionizing irradiation, cyclophosphamide, and 5-fluorouracil) caused an increase in SDF-1 expression and in CXCR4-dependent homing and repopulation by human stem cells transplanted into NOD/SCID mice. Our findings suggest that immature osteoblasts and endothelial cells control stem cell homing, retention, and repopulation by secreting SDF-1, which also participates in host defense responses to DNA damage.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2000 PMID： 11104786 PMCID： PMC381461 DOI： 10.1172/JCI10329

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

60 in total

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190 in total

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