OBJECTIVES: To validate a sensitive and specific screening test for AD and other dementias, assess its reliability and discriminative validity, and present normative data for its use in various applied settings. BACKGROUND: To improve discrimination in screening for AD and dementia, we developed the Memory Impairment Screen (MIS), a 4-minute, four-item, delayed free- and cued-recall test of memory impairment. The MIS uses controlled learning to ensure attention, induce specific semantic processing, and optimize encoding specificity to improve detection of dementia. METHODS: Equivalent forms of the MIS were given at the beginning and end of the testing session to assess alternate forms reliability. Discriminative validity was assessed in a criterion sample of 483 aged individuals, 50 of whom had dementia according to Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised) criteria. RESULTS: The MIS had good alternate forms reliability, high construct validity for memory impairment, and good discriminative validity in terms of sensitivity, specificity, and positive predictive value. We present normative data for use in settings with different base rates (prevalences) of AD and dementia. CONCLUSION: The MIS provides efficient, reliable, and valid screening for AD and other dementias.
OBJECTIVES: To validate a sensitive and specific screening test for AD and other dementias, assess its reliability and discriminative validity, and present normative data for its use in various applied settings. BACKGROUND: To improve discrimination in screening for AD and dementia, we developed the Memory Impairment Screen (MIS), a 4-minute, four-item, delayed free- and cued-recall test of memory impairment. The MIS uses controlled learning to ensure attention, induce specific semantic processing, and optimize encoding specificity to improve detection of dementia. METHODS: Equivalent forms of the MIS were given at the beginning and end of the testing session to assess alternate forms reliability. Discriminative validity was assessed in a criterion sample of 483 aged individuals, 50 of whom had dementia according to Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised) criteria. RESULTS: The MIS had good alternate forms reliability, high construct validity for memory impairment, and good discriminative validity in terms of sensitivity, specificity, and positive predictive value. We present normative data for use in settings with different base rates (prevalences) of AD and dementia. CONCLUSION: The MIS provides efficient, reliable, and valid screening for AD and other dementias.
Authors: Ingo Uttner; Niklas Schurig; Christine A F von Arnim; Christian Lange-Asschenfeldt; Hayrettin Tumani; Matthias W Riepe Journal: J Neurol Date: 2010-06-11 Impact factor: 4.849
Authors: Diana Matallana; Cecilia de Santacruz; Carlos Cano; Pablo Reyes; Rafael Samper-Ternent; Kyriakos S Markides; Kenneth J Ottenbacher; Carlos A Reyes-Ortiz Journal: J Geriatr Psychiatry Neurol Date: 2010-06-10 Impact factor: 2.680
Authors: Joe Verghese; Mohan L Noone; Beena Johnson; Anne F Ambrose; Cuiling Wang; Herman Buschke; Vayyattu G Pradeep; Kizhakkaniyakath Abdul Salam; Kunnukatil S Shaji; Pavagada S Mathuranath Journal: J Am Geriatr Soc Date: 2012-10-05 Impact factor: 5.562