Literature DB >> 9930377

The renin-angiotensin system in diabetic nephropathy: the endothelial connection.

T J Rabelink1, G L Bakris.   

Abstract

In recent years endothelial function has been forwarded a modulator in the pathogenesis of diabetic nephropathy. This review summarizes how an imbalance between endothelium-derived reactive nitrogen species and reactive oxygen species as well as increased expression of the endothelium-derived peptide endothelin-1 may contribute to loss of renal function in diabetes. In addition, the potentially beneficial effects of blockade of the renin-angiotensin system on this endothelial dysbalance is discussed.

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Year:  1998        PMID： 9930377     DOI： 10.1159/000057399

Source DB:  PubMed          Journal:  Miner Electrolyte Metab        ISSN： 0378-0392


  6 in total

1.  ACE-inhibition is superior to endothelin A receptor blockade in preventing abnormal capillary supply and fibrosis of the heart in experimental diabetes.

Authors:  M-L Gross; N Heiss; M Weckbach; A Hansen; A El-Shakmak; A Szabo; K Münter; E Ritz; K Amann
Journal:  Diabetologia       Date:  2004-01-15       Impact factor: 10.122

2.  Endothelin-1, big endothelin-1, and nitric oxide in patients with chronic renal disease and hypertension.

Authors:  Ivanka Mikulić; József Petrik; Kresimir Galesić; Zeljko Romić; Ivana Cepelak; Monika Zeljko-Tomić
Journal:  J Clin Lab Anal       Date:  2009       Impact factor: 2.352

Review 3.  Transforming growth factor beta in cardiovascular development and function.

Authors:  Mohamad Azhar; Jo El J Schultz; Ingrid Grupp; Gerald W Dorn; Pierre Meneton; Daniel G M Molin; Adriana C Gittenberger-de Groot; Thomas Doetschman
Journal:  Cytokine Growth Factor Rev       Date:  2003-10       Impact factor: 7.638

4.  The effect of calcium with or without calcitriol supplementation on renal function in patients with hypovitaminosis d and chronic kidney disease.

Authors:  Ruslinda Mustafar; Rozita Mohd; Norazinizah Ahmad Miswan; Rizna Cader; Halim A Gafor; Marlyn Mohamad; Shamsul Azhar Shah; Nor Azmi Kamaruddin; Norella Kong Chiew Tong
Journal:  Nephrourol Mon       Date:  2014-01-08

Review 5.  Endothelial dysfunction in diabetes mellitus.

Authors:  Hadi A R Hadi; Jassim Al Suwaidi
Journal:  Vasc Health Risk Manag       Date:  2007

6.  Antioxidant effect of endothelin-1 receptor antagonist protects the rat kidney against chronic injury induced by hypertension and hyperglycemia.

Authors:  Agnaldo Caires; Marcia Bastos Convento; Bianca Castino; Ala Moana Leme; Edson de Andrade Pessoa; Alef Aragão; Nestor Schor; Fernanda Teixeira Borges
Journal:  J Bras Nefrol       Date:  2019 Oct-Dec
  6 in total

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