BACKGROUND: Mania with chronic course has been overlooked in the recent literature. Our aim was clinically to characterise and validate this form of mania. METHOD: We evaluated 155 people with DSM-III-R mania and assessed their family history, temperament, symptomatology and course. We used a semi-structured interview for mood disorders, as well as the Comprehensive Psychopathological Rating Scale and the Scale for the Assessment of Positive Symptoms. RESULTS: Twenty (13%) had a chronic course arising from a background of hyperthymic temperament and recurrent mania, with a deteriorative pattern. Clinically, they were characterised by a significantly high rate of almost constant euphoria, grandiose delusions and related delusions, but had relatively low rates of sleep disturbance, psychomotor agitation and hypersexuality. CONCLUSION: Even with current therapies a significant number of people with bipolar disorders have a deteriorative outcome associated with the gradual disappearance of acute mania with an increase in megalomanic delusions, alienation from loved ones and decreased likelihood of medical and psychiatric care.
BACKGROUND:Mania with chronic course has been overlooked in the recent literature. Our aim was clinically to characterise and validate this form of mania. METHOD: We evaluated 155 people with DSM-III-R mania and assessed their family history, temperament, symptomatology and course. We used a semi-structured interview for mood disorders, as well as the Comprehensive Psychopathological Rating Scale and the Scale for the Assessment of Positive Symptoms. RESULTS: Twenty (13%) had a chronic course arising from a background of hyperthymic temperament and recurrent mania, with a deteriorative pattern. Clinically, they were characterised by a significantly high rate of almost constant euphoria, grandiose delusions and related delusions, but had relatively low rates of sleep disturbance, psychomotor agitation and hypersexuality. CONCLUSION: Even with current therapies a significant number of people with bipolar disorders have a deteriorative outcome associated with the gradual disappearance of acute mania with an increase in megalomanic delusions, alienation from loved ones and decreased likelihood of medical and psychiatric care.
Authors: Marie de Zelicourt; Roland Dardennes; Hélène Verdoux; Gian Gandhi; Babak Khoshnood; Eric Chomette; Marie-Laure Papatheodorou; Eric T Edgell; Christian Even; Francis Fagnani Journal: Pharmacoeconomics Date: 2003 Impact factor: 4.981
Authors: Mari N Maia da Silva; Fábio Henrique de Gobbi Porto; Pedro Maranhão Gomes Lopes; Catarina Sodré de Castro Prado; Norberto Anízio Ferreira Frota; Candida Helena Lopes Alves; Gilberto Sousa Alves Journal: Front Psychiatry Date: 2021-12-02 Impact factor: 4.157
Authors: Renato de Filippis; Giulia Menculini; Martina D'Angelo; Elvira Anna Carbone; Alfonso Tortorella; Pasquale De Fazio; Luca Steardo Journal: Front Psychiatry Date: 2022-07-29 Impact factor: 5.435