OBJECTIVE: To explore bidirectional comorbidity between bipolar disorder (BPD) and obsessive-compulsive disorder (OCD) in youth and to examine the symptom profile and clinical correlates of both disorders in the context of reciprocal comorbidity and ascertainment status. METHODS: Two samples of consecutively referred youth (ages 6-17 years) ascertained contemporaneously for respective studies of BPD and OCD were compared using clinical and scalar assessment and structured diagnostic interviews. RESULTS: A total of 21% (17/82) of the BPD subjects and 15% (19/125) of the OCD subjects met DSM-III-R diagnostic criteria for both disorders. In the presence of BPD, youth with OCD more frequently experienced hoarding/saving obsessions and compulsions along with a clinical profile of greater comorbidity, poorer global functioning, and higher rate of hospitalization that is characteristic of BPD. Multiple anxiety disorders (> or = 3), especially generalized anxiety disorder and social phobia, were present at a higher frequency when OCD and BPD were comorbid than otherwise. In subjects with comorbid OCD and BPD, the primary disorder of ascertainment was associated with an earlier onset and more severe impairment. CONCLUSIONS: An unexpectedly high rate of comorbidity between BPD and OCD was observed in youth irrespective of primary ascertainment diagnosis. In youth with comorbid OCD and BPD, the clinical characteristics of each disorder run true and are analogues to their clinical presentation in youth without reciprocal comorbidity, with the exception of increased risk for obsessions and compulsions of hoarding/saving and comorbidity with other anxiety disorders.
OBJECTIVE: To explore bidirectional comorbidity between bipolar disorder (BPD) and obsessive-compulsive disorder (OCD) in youth and to examine the symptom profile and clinical correlates of both disorders in the context of reciprocal comorbidity and ascertainment status. METHODS: Two samples of consecutively referred youth (ages 6-17 years) ascertained contemporaneously for respective studies of BPD and OCD were compared using clinical and scalar assessment and structured diagnostic interviews. RESULTS: A total of 21% (17/82) of the BPD subjects and 15% (19/125) of the OCD subjects met DSM-III-R diagnostic criteria for both disorders. In the presence of BPD, youth with OCD more frequently experienced hoarding/saving obsessions and compulsions along with a clinical profile of greater comorbidity, poorer global functioning, and higher rate of hospitalization that is characteristic of BPD. Multiple anxiety disorders (> or = 3), especially generalized anxiety disorder and social phobia, were present at a higher frequency when OCD and BPD were comorbid than otherwise. In subjects with comorbid OCD and BPD, the primary disorder of ascertainment was associated with an earlier onset and more severe impairment. CONCLUSIONS: An unexpectedly high rate of comorbidity between BPD and OCD was observed in youth irrespective of primary ascertainment diagnosis. In youth with comorbid OCD and BPD, the clinical characteristics of each disorder run true and are analogues to their clinical presentation in youth without reciprocal comorbidity, with the exception of increased risk for obsessions and compulsions of hoarding/saving and comorbidity with other anxiety disorders.
Authors: M F Flament; A Whitaker; J L Rapoport; M Davies; C Z Berg; K Kalikow; W Sceery; D Shaffer Journal: J Am Acad Child Adolesc Psychiatry Date: 1988-11 Impact factor: 8.829
Authors: W K Goodman; L H Price; S A Rasmussen; C Mazure; R L Fleischmann; C L Hill; G R Heninger; D S Charney Journal: Arch Gen Psychiatry Date: 1989-11
Authors: Meredith N Braskie; Omid Kohannim; Neda Jahanshad; Ming-Chang Chiang; Marina Barysheva; Arthur W Toga; John M Ringman; Grant W Montgomery; Katie L McMahon; Greig I de Zubicaray; Nicholas G Martin; Margaret J Wright; Paul M Thompson Journal: Neuroimage Date: 2013-05-30 Impact factor: 6.556
Authors: Jack Samuels; Marco A Grados; Mark A Riddle; O Joseph Bienvenu; Fernando S Goes; Bernadette Cullen; Ying Wang; Benjamin D Greenberg; Abby J Fyer; James T McCracken; Dan Geller; Dennis L Murphy; James A Knowles; Steven A Rasmussen; Nicole C McLaughlin; John Piacentini; David L Pauls; S Evelyn Stewart; Yin-Yao Shugart; Brion Maher; Ann E Pulver; Gerald Nestadt Journal: J Obsessive Compuls Relat Disord Date: 2014-10-01 Impact factor: 1.677
Authors: Meredith N Braskie; Neda Jahanshad; Arthur W Toga; Katie L McMahon; Greig I de Zubicaray; Nicholas G Martin; Margaret J Wright; Paul M Thompson Journal: Bioarchitecture Date: 2012-09-01