| Literature DB >> 9918700 |
F Esclaire1, G Kisby, P Spencer, J Milne, M Lesort, J Hugon.
Abstract
As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures-normally modulated by glutamate-increases after treatment with the aglycone of cycasin, a cycad-derived toxin whose concentration in Chamorro food varies with disease incidence. Elevated Tau gene expression in vitro is coincident with increased cycasin-related DNA adducts and reduced DNA repair. Cycasin and endogenous glutamate may together promote the accumulation of tau protein and neuronal degeneration in Western Pacific ALS/PDC. Copyright 1999 Academic Press.Entities:
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Year: 1999 PMID： 9918700 DOI： 10.1006/exnr.1998.6962
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330