Literature DB >> 33550390

Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC.

Glen E Kisby1, Jason L Eriksen2, Anna C Chlebowski1, Peter S Spencer3.   

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Year:  2021        PMID: 33550390      PMCID: PMC8786491          DOI: 10.1093/jnen/nlab006

Source DB:  PubMed          Journal:  J Neuropathol Exp Neurol        ISSN: 0022-3069            Impact factor:   3.685


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  15 in total

1.  Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy.

Authors:  Wan Yang; Randall L Woltjer; Izabela Sokal; Catherine Pan; Yan Wang; Mary Brodey; Elaine R Peskind; James B Leverenz; Jing Zhang; Daniel P Perl; Douglas R Galasko; Thomas J Montine
Journal:  Am J Pathol       Date:  2007-08-03       Impact factor: 4.307

2.  The Guam cycad toxin methylazoxymethanol damages neuronal DNA and modulates tau mRNA expression and excitotoxicity.

Authors:  F Esclaire; G Kisby; P Spencer; J Milne; M Lesort; J Hugon
Journal:  Exp Neurol       Date:  1999-01       Impact factor: 5.330

3.  Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains.

Authors:  Bert M Verheijen; Satoru Morimoto; Ryogen Sasaki; Kiyomitsu Oyanagi; Yasumasa Kokubo; Shigeki Kuzuhara; Fred W van Leeuwen
Journal:  J Neuropathol Exp Neurol       Date:  2020-08-01       Impact factor: 3.685

4.  Unusual tau pathology of the cerebellum in patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex from the Kii Peninsula, Japan.

Authors:  Satoru Morimoto; Hiroyuki Hatsuta; Yasumasa Kokubo; Yuta Nakano; Masato Hasegawa; Misao Yoneda; Yoshifumi Hirokawa; Shigeki Kuzuhara; Taizo Shiraishi; Shigeo Murayama
Journal:  Brain Pathol       Date:  2018-03       Impact factor: 6.508

5.  Content of the neurotoxins cycasin (methylazoxymethanol beta-D-glucoside) and BMAA (beta-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros.

Authors:  G E Kisby; M Ellison; P S Spencer
Journal:  Neurology       Date:  1992-07       Impact factor: 9.910

Review 6.  Etiology of Retinal and Cerebellar Pathology in Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex.

Authors:  Peter S Spencer
Journal:  Eye Brain       Date:  2020-07-16

7.  Comparative potencies of induction of point mutations and genetic duplications by the methylating agents methylazoxymethanol and dimethyl sulfate in bacteria.

Authors:  George R Hoffmann; David J Crowley; Pia J Theophiles
Journal:  Mutagenesis       Date:  2002-09       Impact factor: 3.000

Review 8.  Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?

Authors:  Glen E Kisby; Peter S Spencer
Journal:  Int J Environ Res Public Health       Date:  2011-09-29       Impact factor: 3.390

9.  Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam.

Authors:  Bert M Verheijen; Tomoyo Hashimoto; Kiyomitsu Oyanagi; Fred W van Leeuwen
Journal:  Acta Neuropathol Commun       Date:  2017-11-09       Impact factor: 7.801

10.  Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex).

Authors:  Peter S Spencer; Valerie S Palmer; Tameko Kihira; Sohei Yoshida; Jacques Reis; Momoko Yabushita; Yoshiro Yase
Journal:  eNeurologicalSci       Date:  2020-02-11
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