Literature DB >> 9918277

Stroke--a medical emergency.

C Lott1, H J Hennes, W Dick.   

Abstract

Stroke is the third leading cause of death and number one cause of disability in industrialised countries. A number of new therapeutic approaches are currently in development for use in the acute phase of ischaemic stroke and all trials have, to date, demonstrated the importance of early diagnosis and subsequent initiation of treatment. It is well known that, for most patients, there is a long delay between the onset of symptoms and the start of treatment. A number of factors are responsible for this time delay: signs and symptoms often go unrecognised by patients, relatives, and bystanders and, unlike trauma or myocardial infarction, stroke is not given a high priority by medical staff. Studies into the pathophysiology of acute ischaemic stroke have indicated that treatment options are likely to be optimised when early signs of stroke are recognised and treatment is initiated within six hours of symptom onset. Although a small number of stroke patients are treated as emergencies and attended to by the emergency medical services within this time window, this number could easily be increased by intensified public and emergency personnel education. In the future, it is hoped that treatments which must be administered within the first few hours of acute stroke will be able to be initiated by the emergency medical services. In the same way that hospitals are notified and prepared in advance to receive trauma victims, early notification by the emergency medical services about stroke patients would enable stroke teams to be present at admission, thus improving the likelihood of a better outcome for patients.

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Mesh:

Year:  1999        PMID: 9918277      PMCID: PMC1343243          DOI: 10.1136/emj.16.1.2

Source DB:  PubMed          Journal:  J Accid Emerg Med        ISSN: 1351-0622


  19 in total

1.  Trials of streptokinase in severe acute ischaemic stroke.

Authors:  G A Donnan; S M Davis; B R Chambers; P C Gates; G J Hankey; J J McNeil; D Rosen; E G Stewart-Wynne; R R Tuck
Journal:  Lancet       Date:  1995-03-04       Impact factor: 79.321

2.  Thresholds in cerebral ischemia - the ischemic penumbra.

Authors:  J Astrup; B K Siesjö; L Symon
Journal:  Stroke       Date:  1981 Nov-Dec       Impact factor: 7.914

3.  Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats.

Authors:  J W McDonald; F S Silverstein; M V Johnston
Journal:  Neurosci Lett       Date:  1990-02-05       Impact factor: 3.046

4.  The Hamburg Stroke Data Bank: goals, design and preliminary results.

Authors:  K Spitzer; V Becker; A Thie; K Kunze
Journal:  J Neurol       Date:  1989-03       Impact factor: 4.849

5.  Effects of public and professional education on reducing the delay in presentation and referral of stroke patients.

Authors:  M J Alberts; A Perry; D V Dawson; C Bertels
Journal:  Stroke       Date:  1992-03       Impact factor: 7.914

6.  Frequency and accuracy of prehospital diagnosis of acute stroke.

Authors:  R Kothari; W Barsan; T Brott; J Broderick; S Ashbrock
Journal:  Stroke       Date:  1995-06       Impact factor: 7.914

7.  Siriraj stroke score and validation study to distinguish supratentorial intracerebral haemorrhage from infarction.

Authors:  N Poungvarin; A Viriyavejakul; C Komontri
Journal:  BMJ       Date:  1991-06-29

8.  Clinical diagnosis of the acute stroke syndrome.

Authors:  C M Allen
Journal:  Q J Med       Date:  1983

9.  21-Aminosteroid reduces ion shifts and edema in the rat middle cerebral artery occlusion model of regional ischemia.

Authors:  W Young; J C Wojak; V DeCrescito
Journal:  Stroke       Date:  1988-08       Impact factor: 7.914

10.  Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

Authors:  W Hacke; M Kaste; C Fieschi; D Toni; E Lesaffre; R von Kummer; G Boysen; E Bluhmki; G Höxter; M H Mahagne
Journal:  JAMA       Date:  1995-10-04       Impact factor: 56.272

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  5 in total

1.  Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway.

Authors:  Tao Wang; Feng Wang; Lu Yu; Zaiwang Li
Journal:  Am J Transl Res       Date:  2019-09-15       Impact factor: 4.060

2.  Current management of acute ischemic stroke. Part 1: Thrombolytics and the 3-hour window.

Authors:  A M Herd
Journal:  Can Fam Physician       Date:  2001-09       Impact factor: 3.275

3.  Current management of acute ischemic stroke. Part 2: Antithrombotics, neuroprotectives, and stroke units.

Authors:  A M Herd
Journal:  Can Fam Physician       Date:  2001-09       Impact factor: 3.275

4.  Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory.

Authors:  Adchara Janyou; Piyawadee Wicha; Jinatta Jittiwat; Apichart Suksamrarn; Chainarong Tocharus; Jiraporn Tocharus
Journal:  Sci Rep       Date:  2017-09-05       Impact factor: 4.379

Review 5.  The Next Step in the Treatment of Stroke.

Authors:  Nathanael Matei; Justin Camara; John H Zhang
Journal:  Front Neurol       Date:  2021-01-22       Impact factor: 4.003

  5 in total

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