Literature DB >> 9917296

The structure of mithramycin reinvestigated.

S E Wohlert1, E Künzel, R Machinek, C Méndez, J A Salas, J Rohr.   

Abstract

A reinvestigation of the structure of mithramycin, the principal product of Streptomyces argillaceus ATCC 12956, is reported. The structure elucidation was carried out with mithramycin decaacetate (4) using 2D NMR methods, including TOCSY, HMBC, and HSQC experiments. The work resulted in structure 3being confirmed for mithramycin.

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Year:  1999        PMID： 9917296     DOI： 10.1021/np980355k

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  23 in total

1.  Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone.

Authors:  Rajan Pragani; William R Roush
Journal:  Org Lett       Date:  2008-09-23       Impact factor: 6.005

2.  Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis.

Authors:  Ryan Wheeler; Xia Yu; Caixia Hou; Prithiba Mitra; Jhong-Min Chen; Frank Herkules; Dmitri N Ivanov; Oleg V Tsodikov; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2019-11-27       Impact factor: 15.336

3.  "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening.

Authors:  Christopher J Schulze; Walter M Bray; Marcos H Woerhmann; Joshua Stuart; R Scott Lokey; Roger G Linington
Journal:  Chem Biol       Date:  2013-02-21

4.  Effect of complex formation between Zn2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase.

Authors:  Suman Das; Pukhrambam Grihanjali Devi; Sudipta Pal; Dipak Dasgupta
Journal:  J Biol Inorg Chem       Date:  2004-11-18       Impact factor: 3.358

5.  How mithramycin stereochemistry dictates its structure and DNA binding function.

Authors:  Caixia Hou; Jürgen Rohr; Sean Parkin; Oleg V Tsodikov
Journal:  Medchemcomm       Date:  2019-03-28       Impact factor: 3.597

6.  Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.

Authors:  E Fernández; U Weissbach; C Sánchez Reillo; A F Braña; C Méndez; J Rohr; J A Salas
Journal:  J Bacteriol       Date:  1998-09       Impact factor: 3.490

7.  Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

Authors:  Lily L Remsing; Ana M González; Mohammad Nur-e-Alam; M José Fernández-Lozano; Alfredo F Braña; Uwe Rix; Marcos A Oliveira; Carmen Méndez; José A Salas; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2003-05-14       Impact factor: 15.419

8.  Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.

Authors:  Zhiliang Jia; Yong Gao; Liwei Wang; Qiang Li; Jun Zhang; Xiangdong Le; Daoyan Wei; James C Yao; David Z Chang; Suyun Huang; Keping Xie
Journal:  Cancer Res       Date:  2010-01-19       Impact factor: 12.701

Review 9.  Multidrug-resistant cancer cells and cancer stem cells hijack cellular systems to circumvent systemic therapies, can natural products reverse this?

Authors:  Qian Zhang; Yunjiang Feng; Derek Kennedy
Journal:  Cell Mol Life Sci       Date:  2016-09-12       Impact factor: 9.261

10.  Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression.

Authors:  So Young Ahn; Chung-Hyun Cho; Keun-Gyu Park; Hyuek Jong Lee; Sik Lee; Sung Kwang Park; In-Kyu Lee; Gou Young Koh
Journal:  Am J Pathol       Date:  2004-05       Impact factor: 4.307
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