Literature DB >> 9915501

DNA microarrays in drug discovery and development.

C Debouck1, P N Goodfellow.   

Abstract

DNA microarrays can be used to measure the expression patterns of thousands of genes in parallel, generating clues to gene function that can help to identify appropriate targets for therapeutic intervention. They can also be used to monitor changes in gene expression in response to drug treatments. Here, we discuss the different ways in which microarray analysis is likely to affect drug discovery.

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Year:  1999        PMID： 9915501     DOI： 10.1038/4475

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  76 in total

1.  Ligand-receptor binding measured by laser-scanning imaging.

Authors:  P Zuck; Z Lao; S Skwish; J F Glickman; K Yang; J Burbaum; J Inglese
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

2.  Ophthalmology in the post-genomic era.

Authors:  G C Black; M E Boulton; P N Bishop; D McLeod
Journal:  Br J Ophthalmol       Date:  1999-11       Impact factor: 4.638

3.  Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays.

Authors:  M D Kane; T A Jatkoe; C R Stumpf; J Lu; J D Thomas; S J Madore
Journal:  Nucleic Acids Res       Date:  2000-11-15       Impact factor: 16.971

Review 4.  Molecular approaches to contraceptive development.

Authors:  U Natraj
Journal:  J Biosci       Date:  2001-11       Impact factor: 1.826

5.  Quantitative quality control in microarray image processing and data acquisition.

Authors:  X Wang; S Ghosh; S W Guo
Journal:  Nucleic Acids Res       Date:  2001-08-01       Impact factor: 16.971

6.  Robust and efficient synthetic method for forming DNA microarrays.

Authors:  P L Dolan; Y Wu; L K Ista; R L Metzenberg; M A Nelson; G P Lopez
Journal:  Nucleic Acids Res       Date:  2001-11-01       Impact factor: 16.971

Review 7.  Search and discovery strategies for biotechnology: the paradigm shift.

Authors:  A T Bull; A C Ward; M Goodfellow
Journal:  Microbiol Mol Biol Rev       Date:  2000-09       Impact factor: 11.056

8.  Early and late molecular events in neurodegeneration and neuroprotection in Parkinson's disease MPTP model as assessed by cDNA microarray; the role of iron.

Authors:  Moussa B.H. Youdim; Edna Grünblatt; Yona Levites; Gila Maor; Silvia Mandel
Journal:  Neurotox Res       Date:  2002 Nov-Dec       Impact factor: 3.911

9.  [Array technology in skin pharmacology and allergology].

Authors:  J M Baron; H F Merk; R Heise
Journal:  Hautarzt       Date:  2003-03-11       Impact factor: 0.751

Review 10.  Phage display: practicalities and prospects.

Authors:  William G T Willats
Journal:  Plant Mol Biol       Date:  2002-12       Impact factor: 4.076
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