Literature DB >> 11779955

Molecular approaches to contraceptive development.

U Natraj1.   

Abstract

The next generation of contraceptives will be based on the identification of novel molecules essential for reproductive processes and will rely on the refinement of older as well as newer technologies. Functional analysis of naturally occurring reproductive genetic disorders and creation of mice null for specific genes would greatly assist in the choice of genetic targets for contraceptive development. Structure-based design of drugs as exemplified by the preparation of an orally active non-peptide gonadotropin releasing hormone (GnRH) would revolutionize drug formulation and delivery for a peptide analogue. This review examines some of the molecular targets that may change contraceptive choices in the future.

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Year:  2001        PMID： 11779955     DOI： 10.1007/bf02704742

Source DB:  PubMed          Journal:  J Biosci        ISSN： 0250-5991            Impact factor:   1.826


  76 in total

Review 1.  Cyclooxygenases: structural, cellular, and molecular biology.

Authors:  W L Smith; D L DeWitt; R M Garavito
Journal:  Annu Rev Biochem       Date:  2000       Impact factor: 23.643

2.  LH-RH antagonists: design and synthesis of a novel series of peptidomimetics.

Authors:  B De; J J Plattner; E N Bush; H S Jae; G Diaz; E S Johnson; T J Perun
Journal:  J Med Chem       Date:  1989-09       Impact factor: 7.446

3.  A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor.

Authors:  R J DeVita; T F Walsh; J R Young; J Jiang; F Ujjainwalla; R B Toupence; M Parikh; S X Huang; J A Fair; M T Goulet; M J Wyvratt; J L Lo; N Ren; J B Yudkovitz; Y T Yang; K Cheng; J Cui; G Mount; S P Rohrer; J M Schaeffer; L Rhodes; J E Drisko; E McGowan; D E MacIntyre; S Vincent; J R Carlin; J Cameron; R G Smith
Journal:  J Med Chem       Date:  2001-03-15       Impact factor: 7.446

4.  Infertile spermatozoa of c-ros tyrosine kinase receptor knockout mice show flagellar angulation and maturational defects in cell volume regulatory mechanisms.

Authors:  C H Yeung; E Sonnenberg-Riethmacher; T G Cooper
Journal:  Biol Reprod       Date:  1999-10       Impact factor: 4.285

Review 5.  Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: therapeutic implications.

Authors:  R P Millar; Y F Zhu; C Chen; R S Struthers
Journal:  Br Med Bull       Date:  2000       Impact factor: 4.291

6.  The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.

Authors:  M Ruggiu; R Speed; M Taggart; S J McKay; F Kilanowski; P Saunders; J Dorin; H J Cooke
Journal:  Nature       Date:  1997-09-04       Impact factor: 49.962

Review 7.  Human follitropin heterodimerization and receptor binding structural motifs: identification and analysis by a combination of synthetic peptide and mutagenesis approaches.

Authors:  J A Dias
Journal:  Mol Cell Endocrinol       Date:  1996-12-20       Impact factor: 4.102

8.  Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

Authors:  J E Dinchuk; B D Car; R J Focht; J J Johnston; B D Jaffee; M B Covington; N R Contel; V M Eng; R J Collins; P M Czerniak
Journal:  Nature       Date:  1995-11-23       Impact factor: 49.962

Review 9.  Gonadotropin-releasing hormone and its analogs.

Authors:  P M Conn; W F Crowley
Journal:  Annu Rev Med       Date:  1994       Impact factor: 13.739

10.  High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.

Authors:  T Lufkin; D Lohnes; M Mark; A Dierich; P Gorry; M P Gaub; M LeMeur; P Chambon
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205
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