BACKGROUND: The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model. METHODS: Wavelength-dependent and polarization-dependent light scattering properties of cell suspensions were measured. RESULTS: Statistically significant differences were found between the tumorigenic and nontumorigenic cells. CONCLUSIONS. Differences in the light scattering properties of tumorigenic and nontumorigenic cells are attributed to a change in the average size of the scattering centers on the order of a few ten of nanometers. This work is relevant to the development of noninvasive optical methods for cancer diagnosis.
BACKGROUND: The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model. METHODS: Wavelength-dependent and polarization-dependent light scattering properties of cell suspensions were measured. RESULTS: Statistically significant differences were found between the tumorigenic and nontumorigenic cells. CONCLUSIONS. Differences in the light scattering properties of tumorigenic and nontumorigenic cells are attributed to a change in the average size of the scattering centers on the order of a few ten of nanometers. This work is relevant to the development of noninvasive optical methods for cancer diagnosis.
Authors: Eladio Rodriguez-Diaz; Christopher Atkinson; Lisa I Jepeal; Adam Berg; Christopher S Huang; Sandra R Cerda; Michael J OʼBrien; Irving J Bigio; Francis A Farraye; Satish K Singh Journal: Inflamm Bowel Dis Date: 2014-06 Impact factor: 5.325
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Authors: Judith R Mourant; Tamara M Powers; Thérese J Bocklage; Heather M Greene; Maxine H Dorin; Alan G Waxman; Meggan M Zsemlye; Harriet O Smith Journal: Appl Opt Date: 2009-04-01 Impact factor: 1.980
Authors: L B Lovat; K Johnson; G D Mackenzie; B R Clark; M R Novelli; S Davies; M O'Donovan; C Selvasekar; S M Thorpe; D Pickard; R Fitzgerald; T Fearn; I Bigio; S G Bown Journal: Gut Date: 2006-02-09 Impact factor: 23.059