| Literature DB >> 9914524 |
H Okkels1, T E Rasmussen, D K Sanghera, M I Kamboh, T Kristensen.
Abstract
The gene encoding the human plasma protein beta2-glycoprotein I or apolipoprotein H was cloned and its structure determined. The gene which consists of eight exons was shown to span 18 kb and was localized to chromosome 17q23-24. The transcriptional initiation site was assigned to a position 31 bp upstream of the start codon. Several consensus sequence elements relevant for regulation of transcription in liver were seen in the 5'-upstream region of the gene. Exon 1 contains the 5'-UTR together with the signal peptide coding sequences. Short consensus repeats (SCRs) 1, 3, 4, and 5 are encoded by single exons each while SCR2 is encoded by two exons. Exon 8 comprises the region encoding the C-terminal end of beta2-glycoprotein I (from His-310), the stop codon and the 3'-UTR.Entities:
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Year: 1999 PMID： 9914524 DOI： 10.1046/j.1432-1327.1999.00063.x
Source DB: PubMed Journal: Eur J Biochem ISSN： 0014-2956