| Literature DB >> 9892157 |
Abstract
Angiotensin II (AngII) resulting as the end product of a proteolytic cascade initiated by renin inhibits the secretion of renin in the sense of a negative feedback. A direct effect of AngII on renal juxtaglomerular epithelioid cells as the main source of renin secretion is mediated via AngII-AT1 receptors and involves calcium-dependent reactions. These reactions may comprise activation of protein kinase C and activation of chloride channels.Entities:
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Year: 1999 PMID: 9892157
Source DB: PubMed Journal: J Am Soc Nephrol ISSN: 1046-6673 Impact factor: 10.121