Literature DB >> 9891803

Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways.

D DiMaio1, C C Lai, O Klein.   

Abstract

This review describes a mechanism of viral transformation involving activation of cellular signaling pathways. We focus on four viral oncoproteins: the E5 protein of bovine papillomavirus, which activates the platelet-derived growth factor beta receptor; gp55 of spleen focus forming virus, which activates the erythropoietin receptor; polyoma virus middle T antigen, which resembles an activated receptor tyrosine kinase; and LMP-1 of Epstein-Barr virus, which mimics an activated tumor necrosis factor receptor. These examples indicate that diverse viruses induce cell transformation by activating cellular signal transduction pathways. Study of this mechanism of viral transformation will provide new insights into viral tumorigenesis and cellular signal transduction.

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Year:  1998        PMID： 9891803     DOI： 10.1146/annurev.micro.52.1.397

Source DB:  PubMed          Journal:  Annu Rev Microbiol        ISSN： 0066-4227            Impact factor:   15.500


  6 in total

1.  Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest.

Authors:  J Doherty; R Freund
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

2.  Herpesvirus ateles gene product Tio interacts with nonreceptor protein tyrosine kinases.

Authors:  J C Albrecht; U Friedrich; C Kardinal; J Koehn; B Fleckenstein; S M Feller; B Biesinger
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

3.  A lysine-to-arginine change found in natural alleles of the human T-cell lymphotropic/leukemia virus type 1 p12(I) protein greatly influences its stability.

Authors:  R Trovato; J C Mulloy; J M Johnson; S Takemoto; M P de Oliveira; G Franchini
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

4.  In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain.

Authors:  Joanne Oates; Matthew Hicks; Timothy R Dafforn; Daniel DiMaio; Ann M Dixon
Journal:  Biochemistry       Date:  2008-08-02       Impact factor: 3.162

5.  Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.

Authors:  R Novosyadlyy; A Vijayakumar; D Lann; Y Fierz; N Kurshan; D LeRoith
Journal:  Oncogene       Date:  2009-07-20       Impact factor: 9.867

6.  Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

Authors:  Yupeng He; Haruhisa Nakao; Seng-Lai Tan; Stephen J Polyak; Petra Neddermann; Sangeetha Vijaysri; Bertram L Jacobs; Michael G Katze
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103
  6 in total

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