Literature DB >> 10438885

Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest.

J Doherty1, R Freund.   

Abstract

Polyomavirus middle T antigen does not overcome p53-mediated G(1) arrest in mouse embryo fibroblasts. Middle T antigen still associates with the signaling molecules phosphatidylinositol 3-kinase and SHC and activates the transcriptional activity of c-Myc and AP1 in p53-arrested cells. Examination of cell cycle regulatory proteins indicated that p53 does not interfere with these mitogenic signals but acts later in the G(1) phase of the cell cycle.

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Year:  1999        PMID： 10438885      PMCID： PMC104322     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

1.  Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

Authors:  D Lin; M T Shields; S J Ullrich; E Appella; W E Mercer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

Review 2.  Control of transcription factors by signal transduction pathways: the beginning of the end.

Authors:  M Karin; T Smeal
Journal:  Trends Biochem Sci       Date:  1992-10       Impact factor: 13.807

3.  Induction of c-jun protooncogene expression and transcription factor AP-1 activity by the polyoma virus middle-sized tumor antigen.

Authors:  A Schönthal; S Srinivas; W Eckhart
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

4.  WAF1, a potential mediator of p53 tumor suppression.

Authors:  W S el-Deiry; T Tokino; V E Velculescu; D B Levy; R Parsons; J M Trent; D Lin; W E Mercer; K W Kinzler; B Vogelstein
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582

Review 5.  The tumor suppressor p53.

Authors:  L A Donehower; A Bradley
Journal:  Biochim Biophys Acta       Date:  1993-08-23

6.  In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

Authors:  M Harvey; A T Sands; R S Weiss; M E Hegi; R W Wiseman; P Pantazis; B C Giovanella; M A Tainsky; A Bradley; L A Donehower
Journal:  Oncogene       Date:  1993-09       Impact factor: 9.867

7.  Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter.

Authors:  A Gutman; C Wasylyk; B Wasylyk
Journal:  Mol Cell Biol       Date:  1991-10       Impact factor: 4.272

8.  Polyoma virus middle T is essential for virus replication and persistence as well as for tumor induction in mice.

Authors:  R Freund; A Sotnikov; R T Bronson; T L Benjamin
Journal:  Virology       Date:  1992-12       Impact factor: 3.616

9.  p21 is a universal inhibitor of cyclin kinases.

Authors:  Y Xiong; G J Hannon; H Zhang; D Casso; R Kobayashi; D Beach
Journal:  Nature       Date:  1993-12-16       Impact factor: 49.962

10.  The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Authors:  J W Harper; G R Adami; N Wei; K Keyomarsi; S J Elledge
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582
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  2 in total

Review 1.  Natural biology of polyomavirus middle T antigen.

Authors:  K A Gottlieb; L P Villarreal
Journal:  Microbiol Mol Biol Rev       Date:  2001-06       Impact factor: 11.056

2.  Induction and bypass of p53 during productive infection by polyomavirus.

Authors:  Dilip Dey; Jean Dahl; Sayeon Cho; Thomas L Benjamin
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103
  2 in total

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