Literature DB >> 9883536

Genetic linkage analysis of complex genetic traits by using affected sibling pairs.

E R Hauser1, M Boehnke.   

Abstract

We provide an introduction to genetic linkage analysis. We discuss methods for the genetic analysis of common, complex disease such as diabetes, heart disease or hypertension. We describe the analysis of affected sibling pairs and discuss some of the challenges in applying these methods.

Entities:  

Mesh：

Year:  1998        PMID： 9883536

Source DB:  PubMed          Journal:  Biometrics        ISSN： 0006-341X            Impact factor:   2.571


  15 in total

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Journal:  Am J Hum Genet       Date:  2004-05-27       Impact factor: 11.025

3.  Extension of the SIMLA package for generating pedigrees with complex inheritance patterns: environmental covariates, gene-gene and gene-environment interaction.

Authors:  Mike Schmidt; Elizabeth R Hauser; Eden R Martin; Silke Schmidt
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4.  Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing.

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5.  Binary trait mapping in experimental crosses with selective genotyping.

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6.  Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.

Authors:  S Ghosh; R M Watanabe; E R Hauser; T Valle; V L Magnuson; M R Erdos; C D Langefeld; J Balow; D S Ally; K Kohtamaki; P Chines; G Birznieks; H S Kaleta; A Musick; C Te; J Tannenbaum; W Eldridge; S Shapiro; C Martin; A Witt; A So; J Chang; B Shurtleff; R Porter; K Kudelko; A Unni; L Segal; R Sharaf; J Blaschak-Harvan; J Eriksson; T Tenkula; G Vidgren; C Ehnholm; E Tuomilehto-Wolf; W Hagopian; T A Buchanan; J Tuomilehto; R N Bergman; F S Collins; M Boehnke
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7.  SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.

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Journal:  Am J Hum Genet       Date:  2000-06-21       Impact factor: 11.025

8.  Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes.

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Journal:  Am J Hum Genet       Date:  2003-02-03       Impact factor: 11.025

9.  Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

Authors:  J L McCauley; R L Zuvich; Y Bradford; S J Kenealy; N Schnetz-Boutaud; S G Gregory; S L Hauser; J R Oksenberg; D P Mortlock; M A Pericak-Vance; J L Haines
Journal:  Genes Immun       Date:  2009-07-23       Impact factor: 2.676

10.  Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes.

Authors:  M L Hamshere; N M Williams; N Norton; H Williams; A G Cardno; S Zammit; L A Jones; K C Murphy; R D Sanders; G McCarthy; M Y Gray; G Jones; P Holmans; M C O'Donovan; M J Owen; N Craddock
Journal:  J Med Genet       Date:  2005-10-14       Impact factor: 6.318
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