BACKGROUND: Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression. METHODS: We undertook analyses in an attempt to detect loci that influence susceptibility to, or modify the clinical expression of, schizophrenia according to the occurrence of episodes of major depression. We used a logistic regression framework in which lifetime presence/absence of major depression was entered as a covariate in the linkage analysis of our UK schizophrenia affected sibling pair series (168 affected sibling pairs typed for a 10 cM map of microsatellite markers). RESULTS: Inclusion of presence/absence of depression as a covariate detected a genome wide significant linkage signal on chromosome 4q28.3 at 130.7 cM (LOD = 4.59; p = 0.038; increase in maximum LOD over univariate analysis (ILOD) = 3.62). Inclusion of the depression covariate also showed suggestive evidence of linkage on 20q11.21 (LOD = 4.10; expected to occur by chance 0.093 times per genome scan, ILOD = 2.83). CONCLUSIONS: Our findings identify loci that may harbour genes that play a role in susceptibility to, or modify the risk of, episodes of major depression in people with schizophrenia.
BACKGROUND: Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression. METHODS: We undertook analyses in an attempt to detect loci that influence susceptibility to, or modify the clinical expression of, schizophrenia according to the occurrence of episodes of major depression. We used a logistic regression framework in which lifetime presence/absence of major depression was entered as a covariate in the linkage analysis of our UK schizophrenia affected sibling pair series (168 affected sibling pairs typed for a 10 cM map of microsatellite markers). RESULTS: Inclusion of presence/absence of depression as a covariate detected a genome wide significant linkage signal on chromosome 4q28.3 at 130.7 cM (LOD = 4.59; p = 0.038; increase in maximum LOD over univariate analysis (ILOD) = 3.62). Inclusion of the depression covariate also showed suggestive evidence of linkage on 20q11.21 (LOD = 4.10; expected to occur by chance 0.093 times per genome scan, ILOD = 2.83). CONCLUSIONS: Our findings identify loci that may harbour genes that play a role in susceptibility to, or modify the risk of, episodes of major depression in people with schizophrenia.
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Authors: George S Zubenko; Brion Maher; Hugh B Hughes; Wendy N Zubenko; J Scott Stiffler; Barry B Kaplan; Mary L Marazita Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2003-11-15 Impact factor: 3.568
Authors: N M Williams; N Norton; H Williams; B Ekholm; M L Hamshere; Y Lindblom; K V Chowdari; A G Cardno; S Zammit; L A Jones; K C Murphy; R D Sanders; G McCarthy; M Y Gray; G Jones; P Holmans; V Nimgaonkar; R Adolfson; U Osby; L Terenius; G Sedvall; M C O'Donovan; M J Owen Journal: Am J Hum Genet Date: 2003-11-18 Impact factor: 11.025
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Authors: Frederike Schirmbeck; Alexander Georgi; Jana Strohmaier; Christine Schmael; Katja V Boesshenz; Thomas W Mühleisen; Stefan Herms; Per Hoffmann; Rami Abou Jamra; Johannes Schumacher; Wolfgang Maier; Peter Propping; Markus M Nöthen; Sven Cichon; Marcella Rietschel; Thomas G Schulze Journal: J Autism Dev Disord Date: 2008-05-13
Authors: T Bernard Bigdeli; Brion S Maher; Zhongming Zhao; Edwin J C G van den Oord; Dawn L Thiselton; Jingchun Sun; Bradley T Webb; Richard L Amdur; Brandon Wormley; Francis A O'Neill; Dermot Walsh; Brien P Riley; Kenneth S Kendler; Ayman H Fanous Journal: PLoS One Date: 2011-12-29 Impact factor: 3.240
Authors: Natalia A Shnayder; Maxim A Novitsky; Nikolay G Neznanov; Oleg V Limankin; Azat R Asadullin; Artem V Petrov; Diana V Dmitrenko; Ekaterina A Narodova; Natalia V Popenko; Regina F Nasyrova Journal: Genes (Basel) Date: 2022-03-02 Impact factor: 4.096