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Literature DB >> 9882390

Polyomavirus large T antigen binds the transcriptional coactivator protein p300.

Abstract

Using coimmunoprecipitation and glutathione S-transferase pulldown experiments, we found that polyomavirus large T antigen binds to p300 in vivo and in vitro. The N-terminal region of the viral protein, including the pRB binding motif, was dispensable for this interaction, which involved several regions within the C-terminal half of the large T antigen. Interestingly, anti-T antibody coimmunoprecipitated a subspecies of p300 which has high histone acetyltransferase activity.

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Year: 1999 PMID： 9882390 PMCID： PMC104009

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

40 in total

1. Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.

Authors: P Yaciuk; E Moran
Journal: Mol Cell Biol Date: 1991-11 Impact factor: 4.272

2. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function.

Authors: Q Sheng; D Denis; M Ratnofsky; T M Roberts; J A DeCaprio; B Schaffhausen
Journal: J Virol Date: 1997-12 Impact factor: 5.103

Review 3. Versatile molecular glue. Transcriptional control.

Authors: R Janknecht; T Hunter
Journal: Curr Biol Date: 1996-08-01 Impact factor: 10.834

4. The transcriptional coactivators p300 and CBP are histone acetyltransferases.

Authors: V V Ogryzko; R L Schiltz; V Russanova; B H Howard; Y Nakatani
Journal: Cell Date: 1996-11-29 Impact factor: 41.582

5. Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes.

Authors: P B Dallas; P Yaciuk; E Moran
Journal: J Virol Date: 1997-02 Impact factor: 5.103

6. E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity.

Authors: H G Wang; E Moran; P Yaciuk
Journal: J Virol Date: 1995-12 Impact factor: 5.103

7. Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein.

Authors: I Mudrak; E Ogris; H Rotheneder; E Wintersberger
Journal: Mol Cell Biol Date: 1994-03 Impact factor: 4.272

8. The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

Authors: A Srinivasan; A J McClellan; J Vartikar; I Marks; P Cantalupo; Y Li; P Whyte; K Rundell; J L Brodsky; J M Pipas
Journal: Mol Cell Biol Date: 1997-08 Impact factor: 4.272

9. The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.

Authors: M L Avantaggiati; M Carbone; A Graessmann; Y Nakatani; B Howard; A S Levine
Journal: EMBO J Date: 1996-05-01 Impact factor: 11.598

Review 10. Common and unique features of T antigens encoded by the polyomavirus group.

Authors: J M Pipas
Journal: J Virol Date: 1992-07 Impact factor: 5.103

8 in total

1. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: acetylation of large T antigen.

Authors: An-Yong Xie; Vladimir P Bermudez; William R Folk
Journal: Mol Cell Biol Date: 2002-11 Impact factor: 4.272

Polyomavirus large T antigen binds the transcriptional coactivator protein p300.

1. Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.

2. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function.

Review 3. Versatile molecular glue. Transcriptional control.

4. The transcriptional coactivators p300 and CBP are histone acetyltransferases.

5. Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes.

6. E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity.

7. Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein.

8. The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

9. The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.

Review 10. Common and unique features of T antigens encoded by the polyomavirus group.

1. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: acetylation of large T antigen.

2. Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domain.

3. Transactivation of murine cyclin A by polyomavirus large and small T antigens.

4. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation.

5. Activation of CREB/ATF sites by polyomavirus large T antigen.

6. Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.

7. Transactivation of E2F-regulated genes by polyomavirus large T antigen: evidence for a two-step mechanism.

8. Induction and bypass of p53 during productive infection by polyomavirus.