| Literature DB >> 988172 |
S K Bhattacharya, P K Reddy, S Ghosal, A K Singh, P V Sharma.
Abstract
CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that swertiamarin and mangiferin antagonize each other in vivo and thereby reverse their CNS effects.Entities:
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Year: 1976 PMID： 988172 DOI： 10.1002/jps.2600651037
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534