| Literature DB >> 9880073 |
P S Senanayake1, R R Smeby, A S Martins, A Moriguchi, H Kumagai, D Ganten, K B Brosnihan.
Abstract
We analyzed by high-performance liquid chromatography and radioimmunoassay angiotensin I (Ang I), Ang II, Ang-(1-7), and metabolites in the adrenal, kidney and heart of normotensive female Sprague-Dawley (SD) and transgenic hypertensive [TGR(mRen-2)27] rats carrying the murine Ren-2d renin gene. The monogenetic model of hypertensive rats had significant increases in adrenal Ang II; whereas in the kidney Ang II was unchanged, but Ang I and Ang-(1-7) were significantly lower. Cardiac Ang I, Ang II, and Ang-(2-10) were significantly reduced in transgenic rats, while Ang-(2-7) was increased. In SD and transgenic rats kidney and adrenal angiotensins increased primarily during estrus or proestrus. In female transgenic rats the increased adrenal Ang II and the sustained renal Ang II may contribute to the established phase of hypertension.Entities:
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Year: 1998 PMID： 9880073 DOI： 10.1016/s0196-9781(98)00123-5
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750