M Elsheikh1, G S Conway. 1. Department of Endocrinology, Middlesex Hospital, London, UK.
Abstract
OBJECTIVE: To evaluate risk factors for coronary artery disease in women with Turner's syndrome which may contribute to the increased incidence of premature cardiovascular death noted in this disorder. DESIGN: Comparison of clinical and biochemical parameters in women with Turner's syndrome with those in women with normal karyotype. PATIENTS: Ninety-one women with Turner's syndrome attending a dedicated adult Turner's syndrome clinic and 22 control subjects were studied. MEASUREMENTS: Recumbent blood pressure, body mass index (BMI), fasting total cholesterol, triglycerides and high density lipoproteins (HDL) were measured in both study groups. RESULTS: Women with Turner's syndrome were more obese compared with women with a normal karyotype. They were more likely to be hypertensive and the obese patients had higher serum triglyceride concentrations. Hypertension was independent of obesity and may be under-recognized because of failure to compare with age-matched normal ranges. Lipoprotein changes were accounted for by the obesity. CONCLUSIONS: Women with Turner's syndrome may be at increased risk of developing coronary artery disease as a result of the higher frequency of hypertension and obesity. Routine screening of this population for risk factors for ischaemic heart disease is recommended.
OBJECTIVE: To evaluate risk factors for coronary artery disease in women with Turner's syndrome which may contribute to the increased incidence of premature cardiovascular death noted in this disorder. DESIGN: Comparison of clinical and biochemical parameters in women with Turner's syndrome with those in women with normal karyotype. PATIENTS: Ninety-one women with Turner's syndrome attending a dedicated adult Turner's syndrome clinic and 22 control subjects were studied. MEASUREMENTS: Recumbent blood pressure, body mass index (BMI), fasting total cholesterol, triglycerides and high density lipoproteins (HDL) were measured in both study groups. RESULTS:Women with Turner's syndrome were more obese compared with women with a normal karyotype. They were more likely to be hypertensive and the obesepatients had higher serum triglyceride concentrations. Hypertension was independent of obesity and may be under-recognized because of failure to compare with age-matched normal ranges. Lipoprotein changes were accounted for by the obesity. CONCLUSIONS:Women with Turner's syndrome may be at increased risk of developing coronary artery disease as a result of the higher frequency of hypertension and obesity. Routine screening of this population for risk factors for ischaemic heart disease is recommended.
Authors: Sarah A Lawson; Elaine M Urbina; Iris Gutmark-Little; Philip R Khoury; Zhiqian Gao; Philippe F Backeljauw Journal: J Clin Endocrinol Metab Date: 2014-06-24 Impact factor: 5.958