Literature DB >> 9873699

Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries.

L Bhat1, Y Liu, S F Victory, R H Himes, G I Georg.   

Abstract

A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

Entities:  

Mesh:

Substances:

Year:  1998        PMID: 9873699     DOI: 10.1016/s0960-894x(98)00551-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Modern natural products drug discovery and its relevance to biodiversity conservation.

Authors:  David G I Kingston
Journal:  J Nat Prod       Date:  2010-12-07       Impact factor: 4.050

2.  Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach.

Authors:  Neil Brown; Ge Gao; Machiko Minatoya; Baohan Xie; David Vandervelde; Gerald H Lushington; Jean-Pierre H Perchellet; Elisabeth M Perchellet; Kyle R Crow; Keith R Buszek
Journal:  J Comb Chem       Date:  2008-08-12

3.  Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis.

Authors:  Neil Brown; Baohan Xie; Nataliya Markina; David Vandervelde; Jean-Pierre H Perchellet; Elisabeth M Perchellet; Kyle R Crow; Keith R Buszek
Journal:  Bioorg Med Chem Lett       Date:  2008-07-24       Impact factor: 2.823

Review 4.  Modifications of human carboxylesterase for improved prodrug activation.

Authors:  Jason M Hatfield; Monika Wierdl; Randy M Wadkins; Philip M Potter
Journal:  Expert Opin Drug Metab Toxicol       Date:  2008-09       Impact factor: 4.481

Review 5.  Design, synthesis and applications of hyaluronic acid-paclitaxel bioconjugates.

Authors:  Francesca Leonelli; Angela La Bella; Luisa Maria Migneco; Rinaldo Marini Bettolo
Journal:  Molecules       Date:  2008-02-12       Impact factor: 4.411

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.