Literature DB >> 9873609

NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.

J Yuan1, X Chen, R Brodbeck, R Primus, J Braun, J W Wasley, A Thurkauf.   

Abstract

N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highly selective dopamine D3 receptor antagonists.

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Year:  1998        PMID： 9873609     DOI： 10.1016/s0960-894x(98)00469-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  33 in total

1.  CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.

Authors:  Jianyong Chen; Gregory T Collins; Beth Levant; James Woods; Jeffrey R Deschamps; Shaomeng Wang
Journal:  ACS Med Chem Lett       Date:  2011-08-11       Impact factor: 4.345

Review 2.  The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence.

Authors:  Christian A Heidbreder; Eliot L Gardner; Zheng-Xiong Xi; Panayotis K Thanos; Manolo Mugnaini; Jim J Hagan; Charles R Ashby
Journal:  Brain Res Brain Res Rev       Date:  2005-07

3.  The effects of the novel DA D3 receptor antagonist SR 21502 on cocaine reward, cocaine seeking and cocaine-induced locomotor activity in rats.

Authors:  E Galaj; S Ananthan; M Saliba; Robert Ranaldi
Journal:  Psychopharmacology (Berl)       Date:  2013-09-15       Impact factor: 4.530

4.  Blockade of D3 receptors by YQA14 inhibits cocaine's rewarding effects and relapse to drug-seeking behavior in rats.

Authors:  Rui Song; Guo-Hua Bi; Hai-Ying Zhang; Ri-Fang Yang; Eliot L Gardner; Jin Li; Zheng-Xiong Xi
Journal:  Neuropharmacology       Date:  2013-10-28       Impact factor: 5.250

5.  High-affinity and selective dopamine D₃ receptor full agonists.

Authors:  Jianyong Chen; Beth Levant; Shaomeng Wang
Journal:  Bioorg Med Chem Lett       Date:  2012-07-11       Impact factor: 2.823

6.  Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression.

Authors:  Neil M Richtand; Yanhong Liu; Rebecca Ahlbrand; Juliana R Sullivan; Amy Hauck Newman; Robert K McNamara
Journal:  Synapse       Date:  2010-08       Impact factor: 2.562

Review 7.  Rationale in support of the use of selective dopamine D₃ receptor antagonists for the pharmacotherapeutic management of substance use disorders.

Authors:  Christian Heidbreder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2012-10-28       Impact factor: 3.000

8.  Characterization of [(3) H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand.

Authors:  Claudia Rangel-Barajas; Maninder Malik; Michelle Taylor; Kim A Neve; Robert H Mach; Robert R Luedtke
Journal:  J Neurochem       Date:  2014-08-19       Impact factor: 5.372

9.  The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats.

Authors:  Krista Spiller; Zheng-Xiong Xi; Xiao-Qing Peng; Amy H Newman; Charles R Ashby; Christian Heidbreder; József Gaál; Eliot L Gardner
Journal:  Psychopharmacology (Berl)       Date:  2007-11-06       Impact factor: 4.530

10.  Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.

Authors:  Aixiao Li; Yogesh Mishra; Maninder Malik; Qi Wang; Shihong Li; Michelle Taylor; David E Reichert; Robert R Luedtke; Robert H Mach
Journal:  Bioorg Med Chem       Date:  2013-04-06       Impact factor: 3.641
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