Literature DB >> 9873552

Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers.

P Yuen1, R M Schelkun, B Szoke, K Tarczy-Hornoch.   

Abstract

Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been identified. Their synthesis and preliminary pharmacology are discussed herein.

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Year:  1998        PMID： 9873552     DOI： 10.1016/s0960-894x(98)00440-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Calcium channel blockers and pain therapy.

Authors:  B Cox
Journal:  Curr Rev Pain       Date:  2000

2.  Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel.

Authors:  Christina I Schroeder; Mark L Smythe; Richard J Lewis
Journal:  Mol Divers       Date:  2004       Impact factor: 2.943
  2 in total

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