| Literature DB >> 9873465 |
Q Li1, W Wang, K B Berst, A Claiborne, L Hasvold, K Raye, M Tufano, A Nilius, L L Shen, R Flamm, J Alder, K Marsh, D Crowell, D T Chu, J J Plattner.
Abstract
The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.Entities:
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Year: 1998 PMID： 9873465 DOI： 10.1016/s0960-894x(98)00355-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823