Literature DB >> 9873392

Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.

R Pellicciari1, G Costantino, E Giovagnoni, L Mattoli, I Brabet, J P Pin.   

Abstract

The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.

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Year:  1998        PMID： 9873392     DOI： 10.1016/s0960-894x(98)00265-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Comparative analysis of the ligand-binding sites of the metabotropic glutamate receptors mGluR1-mGluR8.

Authors:  M S Belenikin; I I Baskin; G Costantino; V A Palyulin; R Pellicciari; N S Zefirov
Journal:  Dokl Biochem Biophys       Date:  2002 Sep-Oct       Impact factor: 0.788

2.  A new binding mode of competitive antagonists to metabotropic glutamate receptors exemplified by the mGluR1-receptor antagonist AIDA (RS-aminoindan-1,5-dicarboxylic acid).

Authors:  M S Belenikin; I I Baskin; V A Palyulin; N S Zefirov
Journal:  Dokl Biochem Biophys       Date:  2002 May-Jun       Impact factor: 0.788

3.  Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.

Authors:  Akito Yasuhara; Shigeyuki Chaki
Journal:  Open Med Chem J       Date:  2010-05-27

4.  Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally "frozen" analogues of L-glutamic acid.

Authors:  Beatrice Bechi; David Amantini; Cristina Tintori; Maurizio Botta; Romano di Fabio
Journal:  Beilstein J Org Chem       Date:  2014-05-14       Impact factor: 2.883
  4 in total

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