| Literature DB >> 9873372 |
Y Koga1, Y Kihara, M Okada, Y Inoue, S Tochizawa, K Toga, K Tachibana, Y Kimura, T Nishi, H Hidaka.
Abstract
In order to search for anti-arteriostenotic agents, a series of 2(1H)-quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2 (1H)-quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia.Entities:
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Year: 1998 PMID： 9873372 DOI： 10.1016/s0960-894x(98)00246-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823