Literature DB >> 9871773

New synthetic inhibitors of microtubule depolymerization.

U Klar1, H Graf, O Schenk, B Röhr, H Schulz.   

Abstract

A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.

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Year:  1998        PMID： 9871773     DOI： 10.1016/s0960-894x(98)00226-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.

Authors:  Jielu Zhao; Susan Bane; James P Snyder; Haipeng Hu; Kamalika Mukherjee; Carla Slebodnick; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2011-10-13       Impact factor: 3.641

2.  Subcellular distribution of epothilones in human tumor cells.

Authors:  R B Lichtner; A Rotgeri; T Bunte; B Buchmann; J Hoffmann; W Schwede; W Skuballa; U Klar
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-18       Impact factor: 11.205

3.  Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.

Authors:  P R C Corrêa; R R S Miranda; L P Duarte; G D F Silva; S A Vieira Filho; A A Okuma; F Carazza; J A Morgado-Díaz; P Pinge-Filho; L M Yamauchi; C V Nakamura; S F Yamada-Ogatta
Journal:  Pathog Glob Health       Date:  2012-05       Impact factor: 2.894

4.  Taccalonolide C-6 Analogues, Including Paclitaxel Hybrids, Demonstrate Improved Microtubule Polymerizing Activities.

Authors:  April L Risinger; Shayne D Hastings; Lin Du
Journal:  J Nat Prod       Date:  2021-06-10       Impact factor: 4.803

5.  The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.

Authors:  David G I Kingston; James P Snyder
Journal:  Acc Chem Res       Date:  2014-07-23       Impact factor: 22.384
  5 in total

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