Literature DB >> 9871762

Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors.

J P Gotteland1, C Loubat, B Planty, D Junquéro, A Delhon, S Halazy.   

Abstract

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG2 cells as cholesterol biosynthesis inhibitors.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9871762     DOI： 10.1016/s0960-894x(98)00213-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate.

Authors:  Yahia Nasser Mabkhot; Nahed Ahmed Kaal; Seham Alterary; Salem S Al-Showiman; Thoraya A Farghaly; Mohammad S Mubarak
Journal:  Chem Cent J       Date:  2017-08-03       Impact factor: 4.215

2.  Synthesis of novel Schiff bases using 2-Amino-5-(3-fluoro-4-methoxyphenyl)thiophene-3-carbonitrile and 1,3-Disubstituted pyrazole-4-carboxaldehydes derivatives and their antimicrobial activity.

Authors:  Divyaraj Puthran; Boja Poojary; Nikil Purushotham; Nandam Harikrishna; Soukhyarani Gopal Nayak; Vinuta Kamat
Journal:  Heliyon       Date:  2019-08-26
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.