Literature DB >> 9871747

Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.

I C Sun1, J K Shen, H K Wang, L M Cosentino, K H Lee.   

Abstract

Eleven betulin derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Compound 4 was found to be the most active with EC50 and TI values of 0.00066 microM and 21,515, respectively.

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Year:  1998        PMID： 9871747     DOI： 10.1016/s0960-894x(98)00202-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Study of the betulin molecule in a water environment; ab initio and molecular simulation calculations.

Authors:  Miroslav Pospíšil; Petr Kovář; Robert Vácha; Michal Svoboda
Journal:  J Mol Model       Date:  2011-05-03       Impact factor: 1.810

2.  Conjugates of betulin derivatives with AZT as potent anti-HIV agents.

Authors:  Juan Xiong; Yoshiki Kashiwada; Chin-Ho Chen; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yoshihisa Takaishi
Journal:  Bioorg Med Chem       Date:  2010-07-07       Impact factor: 3.641

3.  New Phosphorus Analogs of Bevirimat: Synthesis, Evaluation of Anti-HIV-1 Activity and Molecular Docking Study.

Authors:  Elwira Chrobak; Krzysztof Marciniec; Aleksandra Dąbrowska; Paweł Pęcak; Ewa Bębenek; Monika Kadela-Tomanek; Andrzej Bak; Maria Jastrzębska; Stanisław Boryczka
Journal:  Int J Mol Sci       Date:  2019-10-21       Impact factor: 5.923

Review 4.  New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity.

Authors:  Ewa Bębenek; Monika Kadela-Tomanek; Elwira Chrobak; Joanna Wietrzyk; Joanna Sadowska; Stanisław Boryczka
Journal:  Med Chem Res       Date:  2016-09-01       Impact factor: 1.965
  4 in total

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