Literature DB >> 9871729

Synthesis and anti-inflammatory activity of chalcone derivatives.

F Herencia1, M L Ferrándiz, A Ubeda, J N Domínguez, J E Charris, G M Lobo, M J Alcaraz.   

Abstract

Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4-7) inhibited cyclo-oxygenase-2 activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model.

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Year:  1998        PMID： 9871729     DOI： 10.1016/s0960-894x(98)00179-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

Review 1.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

2.  The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.

Authors:  Johnathan Dallman; Ashabha Lansakara; Thi Nguyen; Chamitha Weeramange; Wasundara Hulangamuwa; Ryan J Rafferty
Journal:  Medchemcomm       Date:  2019-06-11       Impact factor: 3.597

3.  Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

Authors:  Vineet Kumar; Sarvesh Kumar; Mohammad Hassan; Hailong Wu; Rajesh K Thimmulappa; Amit Kumar; Sunil K Sharma; Virinder S Parmar; Shyam Biswal; Sanjay V Malhotra
Journal:  J Med Chem       Date:  2011-05-19       Impact factor: 7.446

4.  Anti-malarial, cytotoxicity and molecular docking studies of quinolinyl chalcones as potential anti-malarial agent.

Authors:  Asima Hameed; Sara Masood; Aamir Hameed; Ejaz Ahmed; Ahsan Sharif; Muhammad Imran Abdullah
Journal:  J Comput Aided Mol Des       Date:  2019-07-03       Impact factor: 3.686

5.  Role of nuclear factor-kappaB and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 cells.

Authors:  María José Alcaraz; Ana María Vicente; Amparo Araico; José N Dominguez; María Carmen Terencio; María Luisa Ferrándiz
Journal:  Br J Pharmacol       Date:  2004-07-12       Impact factor: 8.739

6.  Effects of 2',6'-dihydroxy-4'-methoxydihidrochalcone on innate inflammatory response.

Authors:  Murilo Luiz Cerutti; Larissa Benvenutti; Roberta Nunes; Silvia Ramos da Silva; Sara Cristiane Barauna; Márcia Maria de Souza; Ângela Malheiros; Letícia Lacava; Nara Lins Meira Quintão; José Roberto Santin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2020-06-16       Impact factor: 3.000

7.  Therapeutic administration of 3,4,5-trimethoxy-4'-fluorochalcone, a selective inhibitor of iNOS expression, attenuates the development of adjuvant-induced arthritis in rats.

Authors:  Javier Rojas; Miguel Payá; Isabel Devesa; José N Dominguez; M Luisa Ferrándiz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-08-02       Impact factor: 3.000

8.  Exploring the influence of steric, electronic and lipophilic descriptors of 1,3-diarly propenones on their anti-inflammatory activity.

Authors:  N M Bhatia; K R Mahadik; M S Bhatia
Journal:  Daru       Date:  2010       Impact factor: 3.117

Review 9.  Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Authors:  Subhash Padhye; Aamir Ahmad; Nikhil Oswal; Fazlul H Sarkar
Journal:  J Hematol Oncol       Date:  2009-09-02       Impact factor: 17.388

10.  Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes.

Authors:  Miral V Lunagariya; Khyati P Thakor; Reena R Varma; Bhargav N Waghela; Chandramani Pathak; Mohan N Patel
Journal:  Medchemcomm       Date:  2017-12-20       Impact factor: 3.597
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