| Literature DB >> 9871717 |
E R Parmee1, H O Ok, M R Candelore, L Tota, L Deng, C D Strader, M J Wyvratt, M H Fisher, A E Weber.
Abstract
A study of 4-acylaminobenzenesulfonamides in a cloned human beta 3 adrenergic receptor assay resulted in the discovery of n-hexylurea, L-755,507 (22). This 0.43 nM beta 3 agonist, which is > 440-fold selective over both beta 1 and beta 2 binding, is among the most potent human beta 3 agonists reported to date.Entities:
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Year: 1998 PMID： 9871717 DOI： 10.1016/s0960-894x(98)00170-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823