Literature DB >> 9871680

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.

J Adams1, M Behnke, S Chen, A A Cruickshank, L R Dick, L Grenier, J M Klunder, Y T Ma, L Plamondon, R L Stein.   

Abstract

Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.

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Year:  1998        PMID： 9871680     DOI： 10.1016/s0960-894x(98)00029-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  150 in total

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9.  One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.

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Review 10.  Molecular recognition with boronic acids-applications in chemical biology.

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Journal:  J Chem Biol       Date:  2013-06-01
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