Literature DB >> 9870779

Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.

N S Hakim1, B Kobienia, E Benedetti, J Bloomer, W D Payne.   

Abstract

MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.

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Year:  1998        PMID: 9870779

Source DB:  PubMed          Journal:  Int Surg        ISSN: 0020-8868


  2 in total

Review 1.  Dose adaptation of antineoplastic drugs in patients with liver disease.

Authors:  Lydia Tchambaz; Chantal Schlatter; Max Jakob; Anita Krähenbühl; Peter Wolf; Stephan Krähenbühl
Journal:  Drug Saf       Date:  2006       Impact factor: 5.606

2.  Methotrexate-associated nonalcoholic fatty liver disease with transaminitis in rheumatoid arthritis.

Authors:  Rajalingham Sakthiswary; Grace Yin Lai Chan; Ee Tzun Koh; Khai Pang Leong; Bernard Yu Hor Thong
Journal:  ScientificWorldJournal       Date:  2014-05-28
  2 in total

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