Literature DB >> 9865383

Treatment of chronic viral hepatitis.

J Main1, B McCarron, H C Thomas.   

Abstract

Interferon-alpha therapy has proved effective for up to 40% of patients with adult-acquired chronic hepatitis B virus (HBV) infection and for 20-25% of those with chronic hepatitis C virus (HCV) infection. Nucleoside analogues, such as lamivudine and famciclovir, are showing promise as antiviral agents for chronic HBV and the combination of interferon-alpha and ribavirin is proving to be successful therapy for 40-50% of patients with chronic HCV. In this article we review current therapy and discuss future strategies of the therapy of chronic viral hepatitis.

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Year:  1998        PMID： 9865383     DOI： 10.1177/095632029800900601

Source DB:  PubMed          Journal:  Antivir Chem Chemother        ISSN： 0956-3202


  8 in total

1.  Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus.

Authors:  Ann D Kwong; Robert S Kauffman; Patricia Hurter; Peter Mueller
Journal:  Nat Biotechnol       Date:  2011-11-08       Impact factor: 54.908

Review 2.  The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection.

Authors:  Stephan Menne; Paul J Cote
Journal:  World J Gastroenterol       Date:  2007-01-07       Impact factor: 5.742

3.  Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon.

Authors:  W Markland; T J McQuaid; J Jain; A D Kwong
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

4.  Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection.

Authors:  U Protzer; M Nassal; P W Chiang; M Kirschfink; H Schaller
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

Review 5.  Combination chemotherapy for hepatitis B virus: the path forward?

Authors:  T Shaw; S Locarnini
Journal:  Drugs       Date:  2000-09       Impact factor: 9.546

6.  Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells.

Authors:  MinKyung Yi; Stanley M Lemon
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

7.  Chronic hepatitis B infection in Canada.

Authors:  G Y Minuk; J Uhanova
Journal:  Can J Infect Dis       Date:  2001-11

Review 8.  Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases.

Authors:  A Rambaldi; B P Jacobs; C Gluud
Journal:  Cochrane Database Syst Rev       Date:  2007-10-17
  8 in total

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