Literature DB >> 9864339

Repair of oxidized bases in the extremely radiation-resistant bacterium Deinococcus radiodurans.

C Bauche1, J Laval.   

Abstract

Deinococcus radiodurans is able to resist and survive extreme DNA damage induced by ionizing radiation and many other DNA-damaging agents. It is believed that it possesses highly efficient DNA repair mechanisms. To characterize the repair pathway of oxidized purines in this bacteria, we have purified, from crude extracts, proteins that recognize these oxidized bases. We report here that D. radiodurans possesses two proteins excising the oxidized purines (formamidopyrimidine and 8-oxoguanine) by a DNA glycosylase-a purinic/apyrimidine lyase mechanism. Moreover, one of those proteins is endowed with a thymine glycol DNA glycosylase activity. One of these proteins could be the homolog of the Escherichia coli Fpg enzyme, which confirms the existence of a base excision repair system in this bacteria.

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Year:  1999        PMID： 9864339      PMCID： PMC103558     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  40 in total

1.  Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli.

Authors:  R J Graves; I Felzenszwalb; J Laval; T R O'Connor
Journal:  J Biol Chem       Date:  1992-07-15       Impact factor: 5.157

Review 2.  The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).

Authors:  M L Michaels; J H Miller
Journal:  J Bacteriol       Date:  1992-10       Impact factor: 3.490

3.  The mechanisms of action of E. coli endonuclease III and T4 UV endonuclease (endonuclease V) at AP sites.

Authors:  J Kim; S Linn
Journal:  Nucleic Acids Res       Date:  1988-02-11       Impact factor: 16.971

4.  8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

Authors:  J Tchou; H Kasai; S Shibutani; M H Chung; J Laval; A P Grollman; S Nishimura
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

5.  Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

Authors:  M L Wood; M Dizdaroglu; E Gajewski; J M Essigmann
Journal:  Biochemistry       Date:  1990-07-31       Impact factor: 3.162

6.  Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.

Authors:  S Boiteux; T R O'Connor; F Lederer; A Gouyette; J Laval
Journal:  J Biol Chem       Date:  1990-03-05       Impact factor: 5.157

7.  AP endonuclease and uracil DNA glycosylase activities in Deinococcus radiodurans.

Authors:  C I Masters; B E Moseley; K W Minton
Journal:  Mutat Res       Date:  1991-05       Impact factor: 2.433

8.  Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene.

Authors:  H Asahara; P M Wistort; J F Bank; R H Bakerian; R P Cunningham
Journal:  Biochemistry       Date:  1989-05-16       Impact factor: 3.162

9.  8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.

Authors:  K C Cheng; D S Cahill; H Kasai; S Nishimura; L A Loeb
Journal:  J Biol Chem       Date:  1992-01-05       Impact factor: 5.157

10.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.

Authors:  S Shibutani; M Takeshita; A P Grollman
Journal:  Nature       Date:  1991-01-31       Impact factor: 49.962
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  10 in total

1.  Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags.

Authors:  Mary S Lipton; Ljiljana Pasa-Tolic'; Gordon A Anderson; David J Anderson; Deanna L Auberry; John R Battista; Michael J Daly; Jim Fredrickson; Kim K Hixson; Heather Kostandarithes; Christophe Masselon; Lye Meng Markillie; Ronald J Moore; Margaret F Romine; Yufeng Shen; Eric Stritmatter; Nikola Tolic'; Harold R Udseth; Amudhan Venkateswaran; Kwong-Kwok Wong; Rui Zhao; Richard D Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-12       Impact factor: 11.205

2.  Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA.

Authors:  Y Matsumoto; Q M Zhang; M Takao; A Yasui; S Yonei
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

Review 3.  Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics.

Authors:  Miral Dizdaroglu; Erdem Coskun; Pawel Jaruga
Journal:  Mutat Res Rev Mutat Res       Date:  2017-02-16       Impact factor: 5.657

4.  Molecular cloning and functional analysis of the MutY homolog of Deinococcus radiodurans.

Authors:  X Li; A L Lu
Journal:  J Bacteriol       Date:  2001-11       Impact factor: 3.490

Review 5.  Oxidative stress resistance in Deinococcus radiodurans.

Authors:  Dea Slade; Miroslav Radman
Journal:  Microbiol Mol Biol Rev       Date:  2011-03       Impact factor: 11.056

6.  Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1.

Authors:  O White; J A Eisen; J F Heidelberg; E K Hickey; J D Peterson; R J Dodson; D H Haft; M L Gwinn; W C Nelson; D L Richardson; K S Moffat; H Qin; L Jiang; W Pamphile; M Crosby; M Shen; J J Vamathevan; P Lam; L McDonald; T Utterback; C Zalewski; K S Makarova; L Aravind; M J Daly; K W Minton; R D Fleischmann; K A Ketchum; K E Nelson; S Salzberg; H O Smith; J C Venter; C M Fraser
Journal:  Science       Date:  1999-11-19       Impact factor: 47.728

7.  Transcriptional analysis of Deinococcus radiodurans reveals novel small RNAs that are differentially expressed under ionizing radiation.

Authors:  Chen-Hsun Tsai; Rick Liao; Brendan Chou; Lydia M Contreras
Journal:  Appl Environ Microbiol       Date:  2014-12-29       Impact factor: 4.792

8.  Purification and some properties of superoxide dismutase from Deinococcus radiophilus, the UV-resistant bacterium.

Authors:  Young Sun Yun; Young Nam Lee
Journal:  Extremophiles       Date:  2004-04-23       Impact factor: 2.395

9.  Iso-superoxide dismutase in Deinococcus grandis, a UV resistant bacterium.

Authors:  Na-Rae Yun; Young Nam Lee
Journal:  J Microbiol       Date:  2009-05-02       Impact factor: 3.422

Review 10.  A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges.

Authors:  Joanna Timmins; Elin Moe
Journal:  Comput Struct Biotechnol J       Date:  2016-04-07       Impact factor: 7.271
  10 in total

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