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Literature DB >> 9861049

Nuclear localization of prostaglandin E2 receptors.

M Bhattacharya¹, K G Peri, G Almazan, A Ribeiro-da-Silva, H Shichi, Y Durocher, M Abramovitz, X Hou, D R Varma, S Chemtob.

Abstract

Prostaglandin E2 receptors (EP) were detected by radioligand binding in nuclear fractions isolated from porcine brain and myometrium. Intracellular localization by immunocytofluorescence revealed perinuclear localization of EPs in porcine cerebral microvascular endothelial cells. Nuclear association of EP1 was also found in fibroblast Swiss 3T3 cells stably overexpressing EP1 and in human embryonic kidney 293 (Epstein-Barr virus-encoded nuclear antigen) cells expressing EP1 fused to green fluorescent protein. High-resolution immunostaining of EP1 revealed their presence in the nuclear envelope of isolated (cultured) endothelial cells and in situ in brain (cortex) endothelial cells and neurons. Stimulation of these nuclear receptors modulate nuclear calcium and gene transcription.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9861049 PMCID： PMC28123 DOI： 10.1073/pnas.95.26.15792

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

34 in total

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