Literature DB >> 985441

Inhibition of polyamine accumulation and deoxyribonucleic acid synthesis in regenerating rat liver.

H Pösö, J Jänne.   

Abstract

Repeated injections of 1,3-diaminopropane into rats after partial hepatectomy caused a repression-type inhibiton of liver ornithine decarboxylase (EC 4.1.1.17) and totally prevented the marked increases in liver putrescine and spermidine concentrations that normally occur in response to partial hepatectomy. The inhibition of polyamine synthesis by diaminopropane was accompanied by a profound decrease (about 80%) in the synthesis of DNA in the regenerating rat liver without any changes in the synthesis of RNA and total liver protein.

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Year:  1976        PMID： 985441      PMCID： PMC1163993          DOI： 10.1042/bj1580485

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Potent inhibition of ornithine decarboxylase by beta,gamma unsaturated substrate analogs.

Authors:  N Relyea; R R Rando
Journal:  Biochem Biophys Res Commun       Date:  1975-11-03       Impact factor: 3.575

2.  Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases.

Authors:  H G Williams-Ashman; A Schenone
Journal:  Biochem Biophys Res Commun       Date:  1972-01-14       Impact factor: 3.575

3.  Ornithine decarboxylase activity in relation to growth of rat liver. Effects of partial hepatectomy, hypertonic infusions, celite injection or other stressful procedures.

Authors:  T R Schrock; N J Oakman; N L Bucher
Journal:  Biochim Biophys Acta       Date:  1970-04-15

4.  Ornithine decarboxylase activity and the accumulation of putrescine at early stages of liver regeneration.

Authors:  E Hölttä; J Jänne
Journal:  FEBS Lett       Date:  1972-06-01       Impact factor: 4.124

5.  Polyamine synthesis in the regenerating rat liver: stimulation of S-adenosyl methionine decarboxylase, and spermidine and spermine synthases after partial hepatectomy.

Authors:  P Hannonen; A Raina; J Jänne
Journal:  Biochim Biophys Acta       Date:  1972-06-26

6.  On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme.

Authors:  J Jänne; H G Williams-Ashman
Journal:  J Biol Chem       Date:  1971-03-25       Impact factor: 5.157

7.  Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase.

Authors:  D H Russell; S H Snyder
Journal:  Mol Pharmacol       Date:  1969-05       Impact factor: 4.436

8.  Regulation of ornithine decarboxylase activity by putrescine and spermidine in rat liver.

Authors:  J Jänne; E Hölttä
Journal:  Biochem Biophys Res Commun       Date:  1974-11-27       Impact factor: 3.575

9.  Stimulation of polyamine synthesis in relation to nucleic acids in regenerating rat liver.

Authors:  A Raina; J Jänne; M Siimes
Journal:  Biochim Biophys Acta       Date:  1966-07-20

10.  Regulation of ornithine decarboxylase in 3T3 cells by putrescine and spermidine: indirect evidence for translational control.

Authors:  J L Clark; J L Fuller
Journal:  Biochemistry       Date:  1975-10-07       Impact factor: 3.162
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  12 in total

1.  Polyamines and their biosynthetic enzymes in Ehrlich ascites-carcinoma cells. Modification of tumour polyamine pattern by diamines.

Authors:  A Kallio; H Pösö; S K Guha; J Jänne
Journal:  Biochem J       Date:  1977-07-15       Impact factor: 3.857

2.  Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S-adenosylmethionine decarboxylase activity.

Authors:  A E Pegg
Journal:  Biochem J       Date:  1977-07-15       Impact factor: 3.857

3.  Effects of exogenous 1,3-diaminopropane and spermidine on senescence of oat leaves : I. Inhibition of protease activity, ethylene production, and chlorophyll loss as related to polyamine content.

Authors:  L M Shih; R Kaur-Sawhney; J Fuhrer; S Samanta; A W Galston
Journal:  Plant Physiol       Date:  1982-12       Impact factor: 8.340

4.  Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts.

Authors:  D R Bethell; A E Pegg
Journal:  Biochem J       Date:  1979-04-15       Impact factor: 3.857

5.  Ornithine decarboxylase and polyamines in liver and kidneys of rats on cyclical regimen of protein-free and protein-containing diets. Relationship to deoxyribonucleic acid synthesis in liver.

Authors:  D C Farwell; J B Miguez; E J Herbst
Journal:  Biochem J       Date:  1977-10-15       Impact factor: 3.857

6.  Ornithine decarboxylase activity and the onset of deoxyribonucleic acid synthesis in regenerating liver.

Authors:  J A McGowan; N Fausto
Journal:  Biochem J       Date:  1978-01-15       Impact factor: 3.857

7.  Effects of aliphatic diamines on rat liver ornithine decarboxylase activity.

Authors:  A E Pegg; C Conover; A Wrona
Journal:  Biochem J       Date:  1978-03-15       Impact factor: 3.857

8.  Reversible inhibition of bacterial growth after specific inhibition of spermidine synthase by dicyclohexylamine.

Authors:  T Mattila; T Honkanen-Buzalski; H Pösö
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

9.  Suppression of the formation of polyamines and macromolecules by DL-alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes.

Authors:  E Hölttä; J Jänne; T Hovi
Journal:  Biochem J       Date:  1979-01-15       Impact factor: 3.857

10.  Antitumor effect of methylglyoxal bis(3-aminopropylamidinohydrazone), a new inhibitor of S-adenosylmethionine and ornithine decarboxylases, on human erythroid leukemia K562 cells.

Authors:  H Hibasami; T Tsukada; S Maekawa; M Sakurai; S Shirakawa; K Nakashima
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333
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