Literature DB >> 3409453

Antitumor effect of methylglyoxal bis(3-aminopropylamidinohydrazone), a new inhibitor of S-adenosylmethionine and ornithine decarboxylases, on human erythroid leukemia K562 cells.

H Hibasami1, T Tsukada, S Maekawa, M Sakurai, S Shirakawa, K Nakashima.   

Abstract

Methylglyoxal bis(3-aminopropylamidinohydrazone (MGBA) inhibited S-adenosylmethionine decarboxylase (AdoMetDC) activity competitively with S-adenosylmethionine (AdoMet), showing a Ki value of 2.60 x 10(-5) M. It also inhibited ornithine decarboxylase competitively with ornithine, showing a Ki value of 3.80 x 10(-5) M. MGBA inhibited the growth of human erythroid leukemia K562 cells. Putrescine, spermidine, and spermine concentrations in MGBA-treated cells were depressed to 19%, 36%, and 66% of the values of control cells, respectively.

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Year:  1988        PMID： 3409453     DOI： 10.1007/bf00273408

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  19 in total

Review 1.  Polyamines in rapid growth and cancer.

Authors:  J Jänne; H Pösö; A Raina
Journal:  Biochim Biophys Acta       Date:  1978-04-06

2.  Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases.

Authors:  H G Williams-Ashman; A Schenone
Journal:  Biochem Biophys Res Commun       Date:  1972-01-14       Impact factor: 3.575

3.  Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.

Authors:  H G Williams-Ashman; G L Coppoc; G Weber
Journal:  Cancer Res       Date:  1972-09       Impact factor: 12.701

4.  Correlation of ultrastructural and functional damage to mitochondria of ascites L1210 cells treated in vivo with methylglyoxal-bis(guanylhydrazone) or ethidium bromide.

Authors:  C W Porter; F Mikles-Robertson; D Kramer; C Dave
Journal:  Cancer Res       Date:  1979-07       Impact factor: 12.701

5.  Polyamine accumulation and biosynthesis in a mouse L1210 leukemia.

Authors:  D H Russell; C C Levy
Journal:  Cancer Res       Date:  1971-03       Impact factor: 12.701

6.  Effects of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor or ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats.

Authors:  C Danzin; M J Jung; N Claverie; J Grove; A Sjoerdsma; J Koch-Weser
Journal:  Biochem J       Date:  1979-06-15       Impact factor: 3.857

7.  Measurement of the amount of ornithine decarboxylase in Saccharomyces cerevisiae and Saccharomyces uvarum by using alpha-[5-14C]difluoromethylornithine.

Authors:  H Pösö; A E Pegg
Journal:  Biochim Biophys Acta       Date:  1983-09-28

8.  Inhibition of polyamine accumulation and deoxyribonucleic acid synthesis in regenerating rat liver.

Authors:  H Pösö; J Jänne
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857

Review 9.  Role of polyamines and their antimetabolites in clinical medicine.

Authors:  J Jänne; E Hölttä; A Kallio; K Käpyaho
Journal:  Spec Top Endocrinol Metab       Date:  1983

10.  Ornithine decarboxylase and spermidine/spermine N1-acetyltransferase are induced in K562 cells by S-adenosylmethionine decarboxylase inhibitor methylglyoxal bis(guanylhydrazone) but not by analogous methylglyoxal bis(butylamidinohydrazone).

Authors:  H Hibasami; T Tsukada; S Maekawa; K Nakashima
Journal:  Biochem Pharmacol       Date:  1986-11-15       Impact factor: 5.858
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