Literature DB >> 984814

Inhibition of aflatoxin formation by 2-mercaptoethanol.

S K Gupta, K K Maggon, T A Venkitasubramanian.   

Abstract

2-Mercaptoethanol inhibits growth of Aspergillus parasiticus NRRL 3240 and aflatoxin formation by the fungus. When added to the resuspended medium, 2-mercaptoethanol inhibited [1-14C]acetate incorporation into both aflatoxins and neutral lipids, thereby showing that it acts at an early stage of aflatoxin biosynthesis. The inhibition is probably due to its chelating action on zinc, which is essential for aflatoxin production. It is proposed that any chelating agent that selectively binds to zinc will inhibit aflatoxin formation.

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Year:  1976        PMID： 984814      PMCID： PMC170064          DOI： 10.1128/aem.32.3.324-326.1976

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  13 in total

1.  The role of H2O2 in the reversible inhibition of RNA synthesis by thiols in E. coli.

Authors:  L Ehrenberg; I Fedorcsák; M Harms-Ringdahl; M Näslund
Journal:  Acta Chem Scand B       Date:  1974

2.  Thin-layer chromatography of aflatoxins.

Authors:  T V Reddy; L Viswanathan; T A Venkitasubramanian
Journal:  Anal Biochem       Date:  1970-12       Impact factor: 3.365

3.  Nicotinamide adenine dinucleotide kinase from Azotobacter vinelandii cells. Reversible inactivation of the enzyme.

Authors:  A E Chung
Journal:  Biochim Biophys Acta       Date:  1968-07-09

4.  Effect of beta-mercaptoethanol on the binary fission in Stylonychia notophora (Stokes).

Authors:  C M Dass; G R Sapra
Journal:  Exp Cell Res       Date:  1966-10       Impact factor: 3.905

5.  Use of dimethyl sulfoxide to control aflatoxin production.

Authors:  G A Bean; G W Rambo
Journal:  Ann N Y Acad Sci       Date:  1975-01-27       Impact factor: 5.691

6.  Leucine aminotransferase. 3. Activation by beta-mercaptoethanol.

Authors:  R T Taylor; W T Jenkins
Journal:  J Biol Chem       Date:  1966-10-10       Impact factor: 5.157

7.  The effect of zinc and phytic acid on the incorporation of 1-14C-acetate into aflatoxin by resting mycelia of Aspergillus parasiticus.

Authors:  S K Gupta; T A Venkitasubramanian
Journal:  Z Lebensm Unters Forsch       Date:  1975-10-31

8.  PRODUCTION OF AFLATOXINS IN SUBMERGED CULTURE.

Authors:  R I MATELES; J C ADYE
Journal:  Appl Microbiol       Date:  1965-03

9.  Aspergillus flavus infection and aflatoxin production in corn: influence of trace elements.

Authors:  E B Lillehoj; W J Garcia; M Lambrow
Journal:  Appl Microbiol       Date:  1974-11

10.  Coconut as a medium for the experimental production of aflatoxin.

Authors:  S N Arseculeratne; L M de Silva; S Wijesundera; C H Bandunatha
Journal:  Appl Microbiol       Date:  1969-07
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  2 in total

Review 1.  Biosynthesis of aflatoxins.

Authors:  K K Maggon; S K Gupta; T A Venkitasubramanian
Journal:  Bacteriol Rev       Date:  1977-12

2.  Inhibition of aflatoxin biosynthesis by tolnaftate.

Authors:  S N Khan; K K Maggon; T A Venkitasubramanian
Journal:  Appl Environ Microbiol       Date:  1978-08       Impact factor: 4.792
  2 in total

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