Literature DB >> 984798

Antiviral effects of virazole in chronic hepatitis B surface antigen-seropositive chimpanzees.

A E Denes, J W Ebert, K R Berquist, B L Murphy, J E Maynard.   

Abstract

Virazole (Ribavirin, ICN 1229), a broad-spectrum, antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis B surface antigen (HB(s) Ag)-seropositive chimpanzees. No significant change in serum hepatitis B surface antigen was noted and no adverse reactions were observed. The role of viral replication in the chronic carrier state of hepatitis B is discussed.

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Year:  1976        PMID： 984798      PMCID： PMC429791          DOI： 10.1128/AAC.10.3.571

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Transmission of type B viral hepatitis to chimpanzees.

Authors:  L F Barker; F V Chisari; P P McGrath; D W Dalgard; R L Kirschstein; J D Almeida; T S Edington; D G Sharp; M R Peterson
Journal:  J Infect Dis       Date:  1973-06       Impact factor: 5.226

2.  Duality of hepatitis B antigen and its antibody. I. Immunofluorescence studies.

Authors:  W J Brzosko; K Madaliński; K Krawczyński; A Nowoslawski
Journal:  J Infect Dis       Date:  1973-04       Impact factor: 5.226

3.  Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus.

Authors:  K R Berquist; J M Peterson; B L Murphy; J W Ebert; J E Maynard; R H Purcell
Journal:  Infect Immun       Date:  1975-09       Impact factor: 3.441

4.  New antigen-antibody system in Australia-antigen-positive hepatitis.

Authors:  J D Almeida; D Rubenstein; E J Stott
Journal:  Lancet       Date:  1971-12-04       Impact factor: 79.321

5.  Prevalence of hepatitis B virus antigen as revealed by direct radioimmune assay with 125 I-antibody.

Authors:  C M Ling; L R Overby
Journal:  J Immunol       Date:  1972-10       Impact factor: 5.422

6.  Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Authors:  R W Sidwell; J H Huffman; G P Khare; L B Allen; J T Witkowski; R K Robins
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

7.  Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.

Authors:  D G Streeter; J T Witkowski; G P Khare; R W Sidwell; R J Bauer; R K Robins; L N Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1973-04       Impact factor: 11.205

8.  Virus-like particles in Australia antigen-associated hepatitis. An immunoelectron microscopic study of human liver.

Authors:  S N Huang; I Millman; A O'Connell; A Aronoff; H Gault; B S Blumberg
Journal:  Am J Pathol       Date:  1972-06       Impact factor: 4.307

9.  [Action of 1-beta-D-ribofuranosyl, 1,2,4-triazol-3-carboxamide on the treatment of acute viral hepatitis].

Authors:  C B Zuñiga; C de Almeida; A C Iervolino; I de O Castro; P A Galvão
Journal:  AMB Rev Assoc Med Bras       Date:  1974-11
  9 in total
  1 in total

Review 1.  Ribavirin and inosiplex: a review of their present status in viral diseases.

Authors:  T W Chang; R C Heel
Journal:  Drugs       Date:  1981-08       Impact factor: 9.546
  1 in total

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