Literature DB >> 9847222

The Ligand Gated Ion Channel Database.

N Le Novère1, J P Changeux.   

Abstract

The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits. A database has been developed to handle the growing wealth of cloned subunits. This database contains nucleic acid sequences, protein sequences, as well as multiple sequence alignments and phylogenetic studies. This database is accessible via the worldwide web (http://www.pasteur.fr/units/neubiomol/LGIC.h tml), where it is continuously updated. A downloadable version is also available [currently v0.1 (98.06)].

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Year:  1999        PMID： 9847222      PMCID： PMC148177          DOI： 10.1093/nar/27.1.340

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  24 in total

1.  LGICdb: the ligand-gated ion channel database.

Authors:  N Le Novère; J P Changeux
Journal:  Nucleic Acids Res       Date:  2001-01-01       Impact factor: 16.971

2.  Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity.

Authors:  Angelo Keramidas; Andrew J Moorhouse; Kerrie D Pierce; Peter R Schofield; Peter H Barry
Journal:  J Gen Physiol       Date:  2002-05       Impact factor: 4.086

3.  Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.

Authors:  Nicolas Le Novère; Thomas Grutter; Jean-Pierre Changeux
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

4.  Multiple receptor liquid chromatographic stationary phases: the co-immobilization of nicotinic receptors, gamma-amino-butyric acid receptors, and N-methyl D-aspartate receptors.

Authors:  Ruin Moaddel; Jean-François Cloix; Gözen Ertem; Irving W Wainer
Journal:  Pharm Res       Date:  2002-01       Impact factor: 4.200

5.  A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor.

Authors:  Ruotian Jiang; Adeline Martz; Sophie Gonin; Antoine Taly; Lia Prado de Carvalho; Thomas Grutter
Journal:  J Biol Chem       Date:  2010-03-22       Impact factor: 5.157

6.  Allosteric nature of P2X receptor activation probed by photoaffinity labelling.

Authors:  Y Bhargava; J Rettinger; A Mourot
Journal:  Br J Pharmacol       Date:  2012-11       Impact factor: 8.739

7.  A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor.

Authors:  Richard J Law; Richard H Henchman; J Andrew McCammon
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-27       Impact factor: 11.205

8.  A conserved Cys-loop receptor aspartate residue in the M3-M4 cytoplasmic loop is required for GABAA receptor assembly.

Authors:  Wen-yi Lo; Emmanuel J Botzolakis; Xin Tang; Robert L Macdonald
Journal:  J Biol Chem       Date:  2008-08-21       Impact factor: 5.157

9.  Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.

Authors:  Severine Chaumont; Caroline André; David Perrais; Eric Boué-Grabot; Antoine Taly; Maurice Garret
Journal:  J Biol Chem       Date:  2013-08-09       Impact factor: 5.157

Review 10.  Neurotransmitter receptor expression and activity during neuronal differentiation of embryonal carcinoma and stem cells: from basic research towards clinical applications.

Authors:  H Ulrich; P Majumder
Journal:  Cell Prolif       Date:  2006-08       Impact factor: 6.831
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