Literature DB >> 11125117

LGICdb: the ligand-gated ion channel database.

N Le Novère1, J P Changeux.   

Abstract

Ligand-Gated Ion Channels (LGIC) are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits and the last two decades revealed an unexpected wealth of genes coding for these subunits. The Ligand-Gated Ion Channel database (LGICdb) has been developed to handle this increasing amount of data. The database aims to provide only one entry for each gene, containing annotated nucleic acid and protein sequences. The repository is carefully structured and the entries can be retrieved by various criteria. In addition to the sequences, the LGICdb provides multiple sequence alignments, phylogenetic analyses and atomic coordinates when available. The database is accessible via the World Wide Web (http://www.pasteur.fr/recherche/banques/LGIC /LGIC.html), where it is continuously updated. The version 16 (September 2000) available for download contained 333 entries covering 34 species.

Mesh：

Substances：

Year:  2001        PMID： 11125117      PMCID： PMC29772          DOI： 10.1093/nar/29.1.294

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  10 in total

1.  A Web interface generator for molecular biology programs in Unix.

Authors:  C Letondal
Journal:  Bioinformatics       Date:  2001-01       Impact factor: 6.937

Review 2.  The glutamate receptor ion channels.

Authors:  R Dingledine; K Borges; D Bowie; S F Traynelis
Journal:  Pharmacol Rev       Date:  1999-03       Impact factor: 25.468

3.  Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells.

Authors:  N Le Novère; J P Changeux
Journal:  J Mol Evol       Date:  1995-02       Impact factor: 2.395

4.  The Ligand Gated Ion Channel Database.

Authors:  N Le Novère; J P Changeux
Journal:  Nucleic Acids Res       Date:  1999-01-01       Impact factor: 16.971

5.  MView: a web-compatible database search or multiple alignment viewer.

Authors:  N P Brown; C Leroy; C Sander
Journal:  Bioinformatics       Date:  1998       Impact factor: 6.937

Review 6.  The transmitter-gated channels: a range of receptor types and structures.

Authors:  E A Barnard
Journal:  Trends Pharmacol Sci       Date:  1996-09       Impact factor: 14.819

7.  P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels.

Authors:  A Nicke; H G Bäumert; J Rettinger; A Eichele; G Lambrecht; E Mutschler; G Schmalzing
Journal:  EMBO J       Date:  1998-06-01       Impact factor: 11.598

8.  Improved tools for biological sequence comparison.

Authors:  W R Pearson; D J Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

Review 9.  Evolutionary history of the ligand-gated ion-channel superfamily of receptors.

Authors:  M O Ortells; G G Lunt
Journal:  Trends Neurosci       Date:  1995-03       Impact factor: 13.837

10.  A comprehensive set of sequence analysis programs for the VAX.

Authors:  J Devereux; P Haeberli; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971
  10 in total
  19 in total

1.  STCDB: Signal Transduction Classification Database.

Authors:  Ming Chen; Susana Lin; Ralf Hofestaedt
Journal:  Nucleic Acids Res       Date:  2004-01-01       Impact factor: 16.971

2.  Binding site stoichiometry and the effects of phosphorylation on human alpha1 homomeric glycine receptors.

Authors:  Luc J Gentet; John D Clements
Journal:  J Physiol       Date:  2002-10-01       Impact factor: 5.182

3.  SVM-Prot: Web-based support vector machine software for functional classification of a protein from its primary sequence.

Authors:  C Z Cai; L Y Han; Z L Ji; X Chen; Y Z Chen
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

4.  Structural and biophysical properties of a synthetic channel-forming peptide: designing a clinically relevant anion selective pore.

Authors:  U Bukovnik; J Gao; G A Cook; L P Shank; M B Seabra; B D Schultz; T Iwamoto; J Chen; J M Tomich
Journal:  Biochim Biophys Acta       Date:  2011-07-31

Review 5.  Molecular function of α7 nicotinic receptors as drug targets.

Authors:  Cecilia Bouzat; Matías Lasala; Beatriz Elizabeth Nielsen; Jeremías Corradi; María Del Carmen Esandi
Journal:  J Physiol       Date:  2017-11-29       Impact factor: 5.182

6.  Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor.

Authors:  Nuriya Mukhtasimova; Chris Free; Steven M Sine
Journal:  J Gen Physiol       Date:  2005-06-13       Impact factor: 4.086

7.  Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating.

Authors:  Xin-Ming Shen; Kinji Ohno; Akira Tsujino; Joan M Brengman; Monique Gingold; Steven M Sine; Andrew G Engel
Journal:  J Clin Invest       Date:  2003-02       Impact factor: 14.808

8.  Identification and functional characterization of a novel acetylcholine-binding protein from the marine annelid Capitella teleta.

Authors:  Thomas McCormack; Robert M Petrovich; Kelly A Mercier; Eugene F DeRose; Matthew J Cuneo; Jason Williams; Katina L Johnson; Patricia W Lamb; Robert E London; Jerrel L Yakel
Journal:  Biochemistry       Date:  2010-03-16       Impact factor: 3.162

9.  A rice glutamate receptor-like gene is critical for the division and survival of individual cells in the root apical meristem.

Authors:  Jing Li; Shihua Zhu; Xinwei Song; Yi Shen; Hanming Chen; Jie Yu; Keke Yi; Yanfen Liu; Valerie J Karplus; Ping Wu; Xing Wang Deng
Journal:  Plant Cell       Date:  2005-12-23       Impact factor: 11.277

10.  Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors.

Authors:  Steeve H Thany; Hélène Tricoire-Leignel
Journal:  Curr Neuropharmacol       Date:  2011-12       Impact factor: 7.363
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.